EphB4
EphB4 is the principal receptor for ephrin-B2 and, together with its ligand, establishes the arterial-venous boundary during vascular development: ephrin-B2 marks arteries while EphB4 marks veins, and their reciprocal signaling prevents aberrant vessel fusion. In adults EphB4 sustains lymphatic and bone remodeling functions, and it is re-expressed in many tumors, including prostate, breast and colorectal cancers, where ligand-independent signaling promotes survival, angiogenesis and metastasis, though ligand-dependent activation can instead suppress growth. This context-dependent duality makes EphB4 both a biomarker and a therapeutic target. Recombinant EphB4 proteins are used for ephrin-B2 binding and kinase studies.
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EphB4 Recombinant Proteins (7)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
