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Art. -Nr.: HY-163523

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PYRIB-SO 2

PYRIB-SO 2 is a potent antimitotic agent. PYRIB-SO 2 shows antiproliferative activity and induces cell cycle arrest at G2/M phase. PYRIB-SO 2 reduces and disruptes microtubule structures. PYRIB-SO 2 binds to the colchicine-binding site (C-BS) of α, β-tubulin.

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Formel: C₁₄H₁₂ClN₃O₄S
Molecular Weight:353.78

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

PYRIB-SO 2 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
HaCaT	IC₅₀	17 nM Compound: 2	Antiproliferative activity against human HaCaT cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay Antiproliferative activity against human HaCaT cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay	[PMID: 38614151]
MCF7	IC₅₀	50 nM Compound: 2	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay	[PMID: 38614151]
MDA-MB-231	IC₅₀	220 nM Compound: 2	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay	[PMID: 38614151]
MDA-MB-468	IC₅₀	9 nM Compound: 2	Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay	[PMID: 38614151]

In Vitro

PYRIB-SO 2 (150 nM; 24 h) induces cell cycle arrest at G2/M phase ^[1].
PYRIB-SO 2 (138 nM; 24 h) reduces and disruptes microtubule structures in MCF7 cells ^[1].
PYRIB-SO 2 (5, 50 µM) reduces the formation of the EBI:β-tubulin adduct ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

MCF7, MDA-MB-468, MDA-MB-231 cells
Concentration:

0-500 nM
Incubation Time:

48 h
Result:

Showed antiproliferative activity with IC₅₀s of 50, 9, 220 nM for MCF7, MDA-MB-468 and MDA-MB-231 cells, respectively.

Cell Cycle Analysis^[1]

Cell Line:

MCF7 cells
Concentration:

150 nM
Incubation Time:

24 h
Result:

Iduced cell cycle arrest at G2/M phase with the percentage of 77%.

Chemical Information

Molecular Weight 353.78
Formel C₁₄H₁₂ClN₃O₄S
SMILES

ClC1=CC(OS(=O)(C2=CC=C(C=C2)N3CCNC3=O)=O)=CN=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Ouellette V, et al. Modification of the phenyl ring B of phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates by pyridinyl moiety leads to novel antimitotics targeting the colchicine-binding site. Bioorg Med Chem Lett. 2024 Jun 1;105:129745. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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