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Art. -Nr.: HY-184100S

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Relcobatinib

(Synonyms: Relcobatinibum)

Relcobatinib (Relcobatinibum) is a ABL1 kinase inhibitor with an IC₅₀ of 12.7 nM against wild-type ABL1 and an IC₅₀ of 43.5 nM against the ABL1^T315I mutant. Relcobatinib inhibits the phosphorylation of CRKL. Relcobatinib exhibits anticancer activity against chronic myeloid leukemia. Relcobatinib can be used in studies related to chronic myeloid leukemia.

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CAS. Nr.: 2767305-95-1
Formel: C₁₈H₁₂D₆FN₅O₃
Molecular Weight:377.40

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Relcobatinib Chemical Structure

CAS. Nr.: 2767305-95-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- Anwendung
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

Abl1

12.7 nM (IC₅₀)

Abl1^T315I

43.5 nM (IC₅₀)

Alle Bcr-Abl Isoform-spezifische Produkte anzeigen :

Abl
Bcr-Abl

In Vitro

Relcobatinib (Compound 95) potently inhibits K562 cell proliferation with an IC₅₀ of 47.8 nM and weakly inhibits HL60 cell proliferation with an IC₅₀ of 3550 nM^[1].
Relcobatinib inhibits wild-type ABL1 kinase activity with an IC₅₀ of 12.7 nM and ABL1^T315I mutant kinase activity with an IC₅₀ of 43.5 nM in a cell-free biochemical assay^[1].
Relcobatinib inhibits CRKL phosphorylation in K562 cells with an IC₅₀ of 66.3 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anwendung

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS. Nr. 2767305-95-1
Unlabeled Cas 2767304-26-5
Molecular Weight 377.40
Formel C₁₈H₁₂D₆FN₅O₃
SMILES

CN1C(C2=C(OC([2H])([2H])[2H])N=CN=C2OC([2H])([2H])[2H])=CC3=CC(NC([C@H]4[C@H](C4)F)=O)=NC=C31
Synonyms

Relcobatinibum
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Joseph P. Lyssikatos, et al. 5- and 6-azaindole compounds for inhibition of bcr-abl tyrosine kinases. WO2022076975A1. WIPO (PCT). 2021-10-04.

[2]. International Nonproprietary
Names for Pharmaceutical
Substances (INN). WHO Drug Information, Vol. 39, No. 4, 2025.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- Anwendung
Chemical Information
Reinheit & Dokumentation
Verweise

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Relcobatinib

Alle Bcr-Abl Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Relcobatinib Related Classifications

HY-184100S Related Classifications