RO27-3225
RO27-3225 is potent and selective melanocortin 4 receptor (MC4R) agonist with an EC50 of 1 nM and 8 nM for MC4R and MC1R, respectively. RO27-3225 shows 30-fold selectivity for MC4R over MC3R. RO27-3225 has neuroprotective and anti-inflammatory effects.
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- CAS. Nr.: 274682-89-2
- Formel: C39H52N12O6
- Molecular Weight:784.91
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
EC50: 1 nM (Melanocortin 4 receptor (MC4R)), 8 nM (MC1R), 675 nM (MC3R) and 5779 nM (MC5R)[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats of both sexes (270-300 g) with haemorrhagic shock[2]
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Dosage:0.012 mg/kg, 0.024 mg/kg, 0.048 mg/kg
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Administration:Intravenous injection
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Result:Reversed haemorrhagic shock, reduced multiple organ damage and improved survival.
Chemical Information
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CAS. Nr. 274682-89-2
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Molecular Weight 784.91
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Formel C39H52N12O6
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Sequence
{Butir}-His-{dPhe}-Arg-Trp-{Sar}-NH2
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Sequence Shortening
{Butir}-H-{dPhe}-RW-{Sar}-NH2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Benoit SC, et al. A novel selective melanocortin-4 receptor agonist reduces food intake in rats and mice without producing aversive consequences. J Neurosci. 2000 May 1;20(9):3442-8. [Content Brief]
[2]. Giuliani D, et al. Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage. Br J Pharmacol. 2007 Mar;150(5):595-603. [Content Brief]
[3]. Zhang Y, et al. Effects of RO27-3225 on neurogenesis, PDGFRβ+ cells and neuroinflammation after cerebral infarction. Int Immunopharmacol. 2020 Feb 11;81:106281. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
RO27-3225 Related Classifications
HY-P2242 Related Classifications
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