RO5353
RO5353 is an orally active inhibitor for p53-MDM2 with an IC50 of 7 nM for MDM2. RO5353 inhibits the proliferation of wild-type p53 cancer cells with an average IC50 of 7 nM. RO5353 exhibits antitumor efficacy and good pharmacokinetic characteristics in mice.
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- CAS. Nr.: 1360821-61-9
- Formel: C29H29Cl2FN4O4S
- Molecular Weight:619.53
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Chemical Information
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CAS. Nr. 1360821-61-9
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Molecular Weight 619.53
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Formel C29H29Cl2FN4O4S
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SMILES
NC(C1=CC(OC)=C(NC([C@H]2[C@H](C3=C(F)C(Cl)=CC=C3)[C@@]4(C(SC(Cl)=C5)=C5NC4=O)[C@H](CC(C)(C)C)N2)=O)C=C1)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
RO5353 Related Classifications
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