RWJ52353
RWJ52353 is a selective, orally active ligand for α2D adrenoceptor, which binds α2D, α2A, α2B and α1 receptors, with Kis of 1.5, 254, 621 and 443 nM. RWJ52353 exhibits analgesic efficacy in mouse abdominal irritation test (MAIT), with an ED50 of 15.1 mg/kg.
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- CAS. Nr.: 245744-10-9
- Formel: C11H10N2S
- Molecular Weight:202.28
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Alpha-2D adrenergic receptor 1.5 nM (Ki) |
Alpha-2A adrenergic receptor 254 nM (Ki) |
α1-adrenergic receptor 443 nM (Ki) |
Alpha-2B adrenergic receptor 621 nM (Ki) |
Chemical Information
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CAS. Nr. 245744-10-9
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Molecular Weight 202.28
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Formel C11H10N2S
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SMILES
C1(C2=CCCC3=C2C=CS3)=CN=CN1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)