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Macrocyclic Compound Library

83 Cited Publications
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Based on 83 publication(s) in Google Scholar

Macrocycles, molecules containing 12-membered or larger rings, are receiving increased attention in small-molecule drug discovery. The reasons are several, including providing access to novel chemical space, challenging new protein targets, showing favorable ADME- and PK-properties. Macrocycles have demonstrated repeated success when addressing targets that have proved to be highly challenging for standard small-molecule drug discovery, especially in modulating macromolecular processes such as protein–protein interactions (PPI). Otherwise, the size and complexity of macrocyclic compounds make possible to ensure numerous and spatially distributed binding interactions, thereby increasing both binding affinity and selectivity.

MCE offers a unique collection of 460 macrocyclic compounds which can be used for drug discovery for high throughput screening (HTS) and high content screening (HCS). MCE Macrocyclic Compound Library is a useful tool for discovering new drugs, especially for “undruggable” targets and protein–protein interactions.

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  • Macrocyclic Compound Library Product Image
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Service

Virtual Screening
Cell-based Compound Screening
Affinity Mass Spectrometry Drug Screening
Data Download
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  • Manual

Compound Screening Libraries

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Top Publications Citing

Use of MCE Products

Description & Advantages

•   A unique collection of 460 macrocyclic compounds that for drug discovery.

•   A useful tool for the discovery of "undruggable" targets such as protein-protein interactions (PPIs) inhibitors.

•   Cyclopeptides, crown ethers, calixarene and so on are included.

•   More detailed compound information with structure, IC50, and other chemical & biological data.

•   NMR and HPLC validated ensure high purity.

•   All compounds are in stock and continuously updated.

Product Details

Formulation

A collection of 460 macrocyclic compounds supplied as Solid

Layout

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates.
This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container

96-well Storage Tubes with Rack

Storage
-80°C
Shipping
Blue ice or dry ice

Documentation

  • PDF
  • Excel
  • SDF
  • Manual

Composition

Bacterial (98)

Antibiotic (97)

Apoptosis (49)

Autophagy (34)

Parasite (25)

Endogenous Metabolite (19)

Somatostatin Receptor (19)

DNA/RNA Synthesis (17)

Fungal (17)

Microtubule/Tubulin (17)

SARS-CoV (17)

Integrin (16)

Reactive Oxygen Species (ROS) (15)

ADC Payloads (13)

Oxytocin Receptor (13)

Complement System (11)

Drug Derivative (11)

mTOR (11)

HCV (10)

NF-κB (10)

Vasopressin Receptor (10)

HCV Protease (9)

HIV (9)

STING (9)

HSP (8)

Interleukin Related (8)

Melanocortin Receptor (8)

CXCR (7)

FKBP (7)

ERK (6)

P-glycoprotein (6)

Radionuclide-Drug Conjugates (RDCs) (6)

YAP (6)

Akt (5)

Calcium Channel (5)

Caspase (5)

Cyclophilin (5)

Cytochrome P450 (5)

Molecular Glues (5)

NO Synthase (5)

Phosphatase (5)

Potassium Channel (5)

Ras (5)

Trk Receptor (5)

FAP (4)

HIF/HIF Prolyl-Hydroxylase (4)

HSV (4)

Mitochondrial Metabolism (4)

p38 MAPK (4)

PD-1/PD-L1 (4)

STAT (4)

VEGFR (4)

Bcl-2 Family (3)

Chloride Channel (3)

Drug Metabolite (3)

EGFR (3)

FLT3 (3)

Glycosidase (3)

Guanylate Cyclase (3)

HDAC (3)

Influenza Virus (3)

LDLR (3)

Mitophagy (3)

MMP (3)

PI3K (3)

PKC (3)

Anaplastic lymphoma kinase (ALK) (2)

CDK (2)

Dengue Virus (2)

Drug Intermediate (2)

EBV (2)

Elastase (2)

Epigenetic Reader Domain (2)

FAK (2)

Flavivirus (2)

GHSR (2)

Histone Demethylase (2)

IFNAR (2)

IGF-1R (2)

JAK (2)

Keap1-Nrf2 (2)

Ligands for Target Protein for PROTAC (2)

Liposome (2)

mAChR (2)

MEK (2)

Neurokinin Receptor (2)

PROTACs (2)

ROS Kinase (2)

Sodium Channel (2)

Telomerase (2)

Urotensin Receptor (2)

Acetyl-CoA Carboxylase (1)

ADC Linkers (1)

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