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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2438 Results for "
decrease
" in MedChemExpress (MCE) Product Catalog:
Products (2438)
2438 Results for "decrease" in MCE Product Catalog:
Synonyms: 2,3-DPG pentasodium
Target:
Forschungsgebiete:
2,3-Diphosphoglyceric acid (2,3-DPG) pentasodium is an intermediate metabolite of the 2,3-BPG shunt in erythrocytes, capable of binding to hemoglobin and modulating oxygen affinity. 2,3-Diphosphoglyceric acid pentasodium stabilizes the deoxyhemoglobin T-state conformation, reduces hemoglobin oxygen affinity, and promotes oxygen release in tissues. 2,3-Diphosphoglyceric acid pentasodium inhibits the growth of Plasmodium falciparum within erythrocytes without causing hemolysis or a decrease in ATP levels. 2,3-Diphosphoglyceric acid pentasodium is useful for research related to malaria and Alzheimer's disease .
Art. -Nr.: HY-113050B
CAS. Nr.: 62868-79-5
Synonyms: 2,3-DPG (pentacyclohexylamine)
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Forschungsgebiete:
2,3-Diphosphoglyceric acid (2,3-DPG) pentacyclohexylamine is an intermediate metabolite of the 2,3-BPG shunt in erythrocytes, capable of binding to hemoglobin and modulating oxygen affinity. 2,3-Diphosphoglyceric acid pentacyclohexylamine stabilizes the deoxyhemoglobin T-state conformation, reduces hemoglobin oxygen affinity, and promotes oxygen release in tissues. 2,3-Diphosphoglyceric acid pentacyclohexylamine inhibits the growth of Plasmodium falciparum within erythrocytes without causing hemolysis or a decrease in ATP levels. 2,3-Diphosphoglyceric acid pentacyclohexylamine is useful for research related to malaria and Alzheimer's disease .
Target:
Art. -Nr.: HY-118301
CAS. Nr.: 1207440-88-7
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ADX71441 is an orally active, blood-brain barrier penetrant positive allosteric modulator of GABAB receptor. ADX71441 potentiates the activity of endogenous GABA at GABAB receptor, with an EC50 of 96 nM. ADX71441 functionally inhibits adenosine transporters and 5-HT2B receptor. ADX71441 produces anxiolytic-like, analgesic, muscle relaxant, hypothermic and overactive bladder inhibitory effects, reduces acute locomotor activity levels, decreases voluntary intake of alcohol and saccharin, attenuates stress-induced neuronal activation, and exhibits anti-hyperalgesic activity .
Art. -Nr.: HY-119771
CAS. Nr.: 35418-52-1
Schizokinen is an orally active iron chelator that chelates ferric iron and ferrous iron via hydroxamate groups, while also chelating cadmium and binding copper for detoxification; Schizokinen reduces labile iron levels, decreases reactive oxygen species, and scavenges free radicals, and it also binds gallium with high affinity. Schizokinen is selectively taken up by bacteria (bacterial), with higher uptake levels in Gram-positive bacteria and negligible uptake in fungi, and its uptake is upregulated under iron-starvation conditions, making it useful for research related to iron overload and bacterial infections .
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KBU2046 is an orally active transforming growth factor-β (TGF-β1) inhibitor. KBU2046 reduces integrin family protein expression, decreases Raf, RIPK1 and ERK phosphorylation to deactivate the ERK signaling pathway, and down-regulates genes linked to TGF-β1 maturation. KBU2046 suppresses tumor cell motility, impedes cancer invasion and metastasis, and inhibits human ESCC growth and metastasis in a murine model. KBU2046 can be used for the researches of triple-negative breast cancer and esophageal squamous cell carcinoma .
Art. -Nr.: HY-12753AR
CAS. Nr.: 197431-02-0
Synonyms: SR35021 hydrochloride (Standard)
Forschungsgebiete:
Debutyldronedarone hydrochloride (Standard) (SR35021 hydrochloride (Standard)) is the analytical standard of Debutyldronedarone (hydrochloride) (HY-12753A). This product is intended for research and analytical applications. Debutyldronedarone hydrochloride (SR35021 hydrochloride) is a Cytochrome P450 enzyme inhibitor and a Thyroid Hormone Receptor inhibitor, and it is a metabolite of Dronedarone (HY-A0016). Debutyldronedarone hydrochloride inhibits the binding of T3 to TRα1 and TRβ1. Debutyldronedarone hydrochloride reduces the incidence of reperfusion-induced ventricular fibrillation in anesthetized rats, while decreasing their heart rate and blood pressure. Debutyldronedarone hydrochloride can be used in studies related to ventricular fibrillation and atrial fibrillation .
Art. -Nr.: HY-12753AS
Synonyms: SR35021-d7 hydrochloride
Art. -Nr.: HY-12753S
CAS. Nr.: 2070015-16-4
Synonyms: SR35021-d7
Art. -Nr.: HY-12753S1
CAS. Nr.: 1346598-70-6
Synonyms: SR35021-dd6 hydrochloride
Art. -Nr.: HY-134878
CAS. Nr.: 2227449-25-2
Forschungsgebiete:
Amyloid-β-Drp1 PPI-IN-1 is an Amyloid-β-Drp1 protein-protein interaction inhibitor. Amyloid-β-Drp1 PPI-IN-1 inhibits Aβ-Drp1 interaction and decreases Drp1 and Aβ levels. Amyloid-β-Drp1 PPI-IN-1 inhibits excessive mitochondrial fission and promotes mitochondrial fusion and biogenesis. Amyloid-β-Drp1 PPI-IN-1 also alleviates oxidative stress and improves mitochondrial function, and can be used for Alzheimer's disease research .
Synonyms: RXP-470
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Forschungsgebiete:
RXP470.1 (RXP-470) is a potent, selective MMP-12 inhibitor with a Ki of 0.2 nM against human MMP-12. RXP470.1 is 2 to 4 orders of magnitude less potent against other MMPs. RXP470.1 significantly reduces atherosclerotic plaque cross-sectional area in mouse. RXP470.1 results in less complex plaques with increased smooth muscle cell:macrophage ratio, less macrophage apoptosis, increased cap thickness, smaller necrotic cores, and decreased incidence of calcification .
Art. -Nr.: HY-139907B
Reinheit: 99.60%
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Forschungsgebiete:
DG013A formate is a zinc-dependent M1-aminopeptidase inhibitor that exhibits inhibitory activity against ERAP1 (IC50 = 33 nM) and ERAP2 (IC50 = 11 nM). DG013A formate enhances SRHFLAFSFR epitope presentation, rescues GSW11 peptide neoantigen presentation, reduces SIINFEKL presentation, modulates the immunopeptidome, decreases HLA-B27 free heavy chain expression, and reduces IL-17A secretion. DG013A formate exhibits antiproliferative activity. DG013A formate can be used for research on autoimmune diseases and melanoma .
Synonyms: 1-Palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine; PAPC; PC(16:0/20:4)
Forschungsgebiete:
1-Palmitoyl-2-arachidonoyl-sn-glycero-3-PC (PAPC) is a phospholipid containing palmitic acid (16:0) and arachidonic acid (20:4) at the sn-1 and sn-2 positions, respectively, that is found in biological membranes. PAPC is oxidized in vivo, and its oxidation products are involved in chronic inflammation and vascular disease. PAPC has been used to study signaling of oxidized phospholipids. Levels of PAPC are decreased in isolated human multiple myeloma cells.
The product specifications provided below refer solely to the active content of 1-PalMitoyl-2-arachidoyllecithin.
The product specifications provided below refer solely to the active content of 1-PalMitoyl-2-arachidoyllecithin.
Art. -Nr.: HY-142140S
CAS. Nr.: 2483831-27-0
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3-epi-25-Hydroxy Vitamin D3-d6 is the deuterated-labeled 3-epi-Calcifediol (HY-32351B). 3-epi-25-hydroxy Vitamin D3 is the C-3 epimer of 25-hydroxy vitamin D3.1 Dietary administration of 3-epi-25-hydroxy vitamin D3 (0.5 and 1 IU/g) decreases levels of serum parathyroid hormone (PTH) in male, but not female, weanling rats.
Art. -Nr.: HY-142240
CAS. Nr.: 2209104-84-5
Synonyms: HSK16149
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Forschungsgebiete:
Crisugabalin is an orally active, selective ligand for the α2δ subunit of voltage-gated calcium channels, with a target IC50 of 3.96 nM in rats. Crisugabalin inhibits the binding of [ 3H]gabapentin to the α2δ subunit, reduces calcium influx, decreases neuronal excitability, and impairs nociceptive transmission. Crisugabalin alleviates mechanical allodynia, neuropathic pain and inflammatory pain in rats, and reduces phase II pain behaviors. Crisugabalin can be used in research related to chronic pain, neuropathic pain, diabetic neuropathy, fibromyalgia, inflammatory pain, diabetic peripheral neuropathy and postherpetic neuralgia.
Art. -Nr.: HY-145514CR
CAS. Nr.: 2624313-16-0
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dTAGV-1 hydrochloride (Standard) is the analytical standard of dTAGV-1 hydrochloride (HY-145514C). This product is intended for research and analytical applications. dTAGV-1 hydrochloride is a selective FKBP12 F36V PROTAC degrader. dTAGV-1 hydrochloride induces rapid degradation of FKBP12 F36V-tagged oncogenic fusion proteins, triggering collapse of downstream cellular signaling pathways, reduced proliferative capacity of cancer cells, and decreased levels of target proteins. dTAGV-1 hydrochloride is applicable to functional validation studies of cancer and undegradable oncoproteins .
Art. -Nr.: HY-146307
CAS. Nr.: 2445565-58-0
TrxR-IN-3 is a thioredoxin reductase (TrxR) inhibitor with an IC50 of 0.12 µM in MDA-MB-231 cells. TrxR-IN-3 inhibits TrxR enzyme activity and suppresses TrxR protein expression. TrxR-IN-3 induces reactive oxygen species (ROS) accumulation, apoptosis, and autophagy. TrxR-IN-3 modulates apoptosis-related proteins by decreasing anti-apoptotic protein levels and increasing caspase cleavage. TrxR-IN-3 modulates autophagy-related proteins by increasing autophagy markers and reducing autophagy substrate proteins. TrxR-IN-3 can be used for breast cancer research .
Art. -Nr.: HY-150683
CAS. Nr.: 3031654-46-0
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NC-III-49-1 is a potent bivalent bromodomain and extraterminal domain (BET) inhibitor. NC-III-49-1 shows binding potential for BRD4-1, BRD4-2, BRD4-T, BRDT-1, BRDT-2, BRDT-T with Kd values of 0.095, 0.32, 0.29, 0.089, 5.5, 0.058 nM, respectively. NC-III-49-1 shows antiproliferative activity. NC-III-49-1 decreases the expression of c-Myc .
Art. -Nr.: HY-155517
CAS. Nr.: 3049730-43-7
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Forschungsgebiete:
INF200 (compound 5) is a sulfonylurea-based inhibitor of NLRP3 and NLRP3-mediated pyroptosis. INF200 has beneficial cardiometabolic effects in rat model of high-fat diet (HFD)-induced metaflammation，and shows anti-inflammatory activity to (10 μM) decreases IL-1β release in human macrophages. INF200 improves glucose and lipid profiles，and attenuates systemic inflammation and biomarkers of cardiac dysfunction (particularly BNP). INF200 also improves myocardial damage-dependent ischemia/reperfusion injury (IRI) in hemodynamic evaluation .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
