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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
paralysis/death
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "paralysis/death" in MCE Product Catalog:
1
1 Cited Publications
Forschungsgebiete:
Azamethiphos is an acetylcholinesterase inhibitor and insecticide. Azamethiphos covalently binds to acetylcholinesterase via phosphorylation, inhibits its activity, causes acetylcholine to accumulate in cholinergic synapses, triggers uncontrolled excitation of cholinergic sites, induces paralysis and leads to death. Azamethiphos can be used as a bath insecticide in salmonid aquaculture to control sea lice infestations, and it exerts acute toxicity to European lobster larvae, including mortality and movement disorders .
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Forschungsgebiete:
Sphingomyelin phosphodiesterase, Bacillus cereus is a sphingomyelin hydrolase and Insecticide. Sphingomyelin phosphodiesterase, Bacillus cereus catalyzes the decomposition of sphingomyelin into ceramide and phosphorylcholine. Sphingomyelin phosphodiesterase, Bacillus cereus causes rapid paralysis and death in injected insects, including German cockroaches and black cutworms. Sphingomyelin phosphodiesterase, Bacillus cereus reduces H2O2 production. Sphingomyelin phosphodiesterase, Bacillus cereus can be used in studies related to sepsis and endophthalmitis .
Art. -Nr.: HY-P5142
CAS. Nr.: 193981-10-1
Synonyms: ω-ACTX-Hv1; ω-Atracotoxin-HV1
Forschungsgebiete:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
Art. -Nr.: HY-W339331
CAS. Nr.: 272451-65-7
Synonyms: NNI-0001
Forschungsgebiete:
Flubendiamide (NNI-0001) is an orally active phthalic diamide insecticide that acts by targeting insect ryanodine receptors (RyRs), causing insect muscle dysfunction, paralysis and death. Flubendiamide disrupts molting, metamorphosis and reproductive processes, induces oxidative stress by increasing the levels of ROS/RNS, MDA and 8OHdG and decreasing the levels of SOD, CAT and GST, activates the CncC/Maf apoptosis pathway, impairs calcium homeostasis, promotes adipogenesis, increases triglyceride accumulation, and upregulates the expression of regulatory factors for adipocyte differentiation and adipogenesis .
Art. -Nr.: HY-Z8942
CAS. Nr.: 65195-57-5
Category:
Target:
Art. -Nr.: HY-15308B
CAS. Nr.: 110415-68-4
Target:
Forschungsgebiete:
Δ²-Avermectin B₁ₐ (Compound 3) is an antiparasitic agent targeting glutamate-gated chloride channels (GluCls) in the neuromuscular system of invertebrates. Δ²-Avermectin B₁ₐ enhances chloride ion influx, leading to hyperpolarization of the neuromuscular cell membrane, inhibition of neural signal transmission, and ultimately paralysis and death of parasites. Δ²-Avermectin B₁ₐ is promising for research of agricultural pests .
Art. -Nr.: HY-114899S
CAS. Nr.: 1189894-02-7
Art. -Nr.: HY-114899R
CAS. Nr.: 35575-96-3
Forschungsgebiete:
Azamethiphos (Standard) is the analytical standard of Azamethiphos (HY-114899). This product is intended for research and analytical applications. Azamethiphos is an acetylcholinesterase inhibitor and insecticide. Azamethiphos covalently binds to acetylcholinesterase via phosphorylation, inhibits its activity, causes acetylcholine to accumulate in cholinergic synapses, triggers uncontrolled excitation of cholinergic sites, induces paralysis and leads to death. Azamethiphos can be used as a bath insecticide in salmonid aquaculture to control sea lice infestations, and it exerts acute toxicity to European lobster larvae, including mortality and movement disorders .
Art. -Nr.: HY-175339
Insecticidal agent 25 (Compound WZ18) is an insecticide targeting the nicotinic acetylcholine receptors (nAChRs) in insect nervous systems. Insecticidal agent 25 disrupts neurotransmission by competitively binding to nAChRs, leading to insect paralysis and death .
Art. -Nr.: HY-206897
CAS. Nr.: 183992-66-7
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Forschungsgebiete:
Insecticidal agent 34 is an orally active insecticide. Insecticidal agent 34 inhibits voltage-gated sodium channel and blocks acetylcholine release. Insecticidal agent 34 induces ataxia, paralysis, curling, tremors/convulsions and progressive death in lepidopteran larvae, inhibits neural activity in the central nervous system, and blocks nerve firing in larval stretch receptor preparations. Insecticidal agent 34 can be used for insecticidal research .
Art. -Nr.: HY-189072
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Forschungsgebiete:
Insecticidal agent 39 (compound I ai) is a potent insecticide that targets Ryanodine Receptor (RyR). The LC50 of Insecticidal agent 39 against M. separata is 0.26 mg/L. Insecticidal agent 39 specifically binds to and activates RyR, inducing the release of Ca 2+ from the sarcoplasmic reticulum into the cytoplasm, which leads to sustained muscle contraction and eventual paralysis and death of the pest. Insecticidal agent 39 can be used in studies related to lepidopteran pest infestation .
Art. -Nr.: HY-N21981
CAS. Nr.: 87095-76-9
Category:
Zingiberaceae Extract Simple Phenylpropanols Scrophulariaceae Extract Phenylpropanoids Plants Bacopa monnieri (Linn.) Wettst. Curcuma comosa Roxb.
Target:
Art. -Nr.: HY-P5142A
Synonyms: ω-ACTX-Hv1 TFA; ω-Atracotoxin-HV1 TFA
Forschungsgebiete:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
