Solasulfone
Solasulfone (Solapsone; Sulfetrone) is an inhibitor of complement protein C1q and β-lactamase. Solasulfone also acts as a chemotherapeutic agent and can be used in cancer research.
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- CAS. Nr.: 133-65-3
- Formel: C30H28N2Na4O14S5
- Molecular Weight:892.83
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Beschreibung
In Vitro
Solasulfone (Compound 35) (30 min) inhibits activation of the classical complement pathway in guinea pig serum, with an IC50 of 130 μM[1].
Solasulfone (0.98 mM; 1 h) inhibits C1r/C1s activity in guinea pig serum via interaction with C1q, with inhibition rates of 18.39% and 18.77% at the concentration of 0.98 mM in two complementary ELISA assays[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 133-65-3
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Molecular Weight 892.83
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Formel C30H28N2Na4O14S5
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SMILES
O=S(C(CC(S(=O)(O[Na])=O)C1=CC=CC=C1)NC2=CC=C(S(=O)(C3=CC=C(NC(S(=O)(O[Na])=O)CC(S(=O)(O[Na])=O)C4=CC=CC=C4)C=C3)=O)C=C2)(O[Na])=O
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Synonyms
Solapsone; Sulfetrone
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Bureeva S, et al. Inhibition of classical pathway of complement activation with negative charged derivatives of bisphenol A and bisphenol disulphates. Bioorganic & medicinal chemistry. 2005 Feb 15;13(4):1045-52. [Content Brief]
[2].
Farhat N, Khan AU. Repurposing FDA approved drug molecules against A B C classes of β-lactamases: a computational biology and molecular dynamics simulations study. J Biomol Struct Dyn. 2024;42(24):13635-13649.
[Content Brief]
[3].
BARDESONO G. Un nuovo chemioterapico, il sulfetrone [A new chemotherapy, sulfetrone]. Minerva Med. 1949 May 26;40(26):802-4. Italian.
[Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Solasulfone Related Classifications
HY-184031 Related Classifications
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