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Art. -Nr.: HY-164923

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SPA107

Name: SPA107
Brand: MedChemExpress
SKU: HY-164923
Availability: PreOrder

(Synonyms: Hemiasterlin methyl ester)

SPA107 (Hemiasterlin methyl ester) is a Hemiasterlin (HY-117371) analog. SPA107 inhibits the polymerization of tubulin, exhibits antimitotic activity (IC₅₀ of 0.5 nM) and cytotoxicity in p53 mutated MCF-7 cell with IC₅₀ of 0.5 nM.

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CAS. Nr.: 179939-69-6
Formel: C₃₁H₄₈N₄O₄
Molecular Weight:540.74

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

SPA107 Chemical Structure

CAS. Nr.: 179939-69-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	0.5 nM Compound: 11, SPA107	Antimitotic activity against human MCF7 cells expressing p53 mutant by MTT assay Antimitotic activity against human MCF7 cells expressing p53 mutant by MTT assay	[PMID: 12608848]
MCF7	IC₅₀	0.5 nM Compound: 11, SPA107	Cytotoxicity activity against human MCF7 cells expressing p53 mutant by MTT assay Cytotoxicity activity against human MCF7 cells expressing p53 mutant by MTT assay	[PMID: 12608848]

Chemical Information

CAS. Nr. 179939-69-6
Molecular Weight 540.74
Formel C₃₁H₄₈N₄O₄
SMILES

COC(/C(C)=C/[C@H](C(C)C)N(C)C([C@H](C(C)(C)C)NC([C@@H](NC)C(C)(C1=CN(C)C2=CC=CC=C12)C)=O)=O)=O
Synonyms

Hemiasterlin methyl ester
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Nieman JA, et al., Synthesis and antimitotic/cytotoxic activity of hemiasterlin analogues. J Nat Prod. 2003 Feb;66(2):183-99. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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