SR-12062
SR-12062 is a Neurotensin receptor 1 (NTSR1) full agonist that modulates NTSR1 to trigger intracellular Ca2+ mobilization. SR-12062 can be used for the research of schizophrenia, parkinson’s disease, drug addiction.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 1623019-77-1
- Formel: C25H25N3O3
- Molecular Weight:415.48
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
|
NTR1 |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
2.05 μM
Compound: 8, SR-12062
|
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
|
[PMID: 24997685] |
SR-12062 (Compound 8) (2 μM) acts as a full agonist of NTSR1 with an EC50 of 2 μM and 99% efficacy relative to NT(8-13), and its activity is blocked by NTSR1 antagonist 5[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS. Nr. 1623019-77-1
-
Molecular Weight 415.48
-
Formel C25H25N3O3
-
SMILES
CC(C)C[C@@H](C(O)=O)NC(CN1C2=CC=C(C3=CC4=C(C=CC=C4)N=C3)C=C2C=C1)=O
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Di Fruscia P, et al. The discovery of indole full agonists of the neurotensin receptor 1 (NTSR1). Bioorg Med Chem Lett. 2014;24(16):3974-3978. [Content Brief]
[2]. Pinkerton AB, et al. Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators. J Med Chem. 2019;62(17):8357-8363. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
SR-12062 Related Classifications
HY-182551 Related Classifications
Powered by Bioz