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Art. -Nr.: HY-182367

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TMN-OMe

TMN-OMe is a blood-brain barrier-permeable GPR39 agonist and a radiotracer for positron emission tomography (PET). TMN-OMe activates GPR39 by recruiting β-arrestin, exhibits highly selective binding ability in the mouse brain, and enables quantitative analysis of GPR39 at the in vivo level. TMN-OMe shows specific uptake in GPR39 knockout mice, Alzheimer's disease model (APP/PS1) mice, and blocking experiments. TMN-OMe facilitates in-depth exploration of changes in GPR39-related mechanisms in neurological diseases and is widely used in Alzheimer's disease research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₁₉H₁₆ClN₇O₂
Molecular Weight:409.83

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

TMN-OMe Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

TMN-OMe (5 nM-33.3 μM; 2 h) activates human GPR39 expressed in CHO-K1 cells with an EC₅₀ of 1.65 μM in a β-arrestin recruitment assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

[¹¹C]TMN-OMe (8.5 MBq; i.v.; single bolus injection) exhibits rapid blood-brain barrier penetration and specific binding to GPR39 in healthy male BALB/c mice, with baseline brain SUV of 0.31 g/mL that is reduced by up to 86.8% under blocking conditions^[1].
[¹¹C]TMN-OMe (8.5 MBq; i.v.; single bolus injection) detects reduced GPR39 levels in the brains of APP/PS1 Alzheimer's disease model mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J (male, 6 months old); GPR39 knockout (male, 6 months old)^[1]
Dosage:

8.5 MBq
Administration:

i.v.; single bolus injection
Result:

Reached brain uptake of 0.31 g/mL SUV in wild-type mice versus 0.09 g/mL SUV in GPR39 knockout mice, representing a 69.4% decrease.
Showed brain uptake of 1.01 %ID/g in wild-type mice versus 0.29 %ID/g in GPR39 knockout mice at 30 min postinjection, a 71% reduction.
Demonstrated wild-type brain uptake of 6.35 PSL/mm² versus 4.58 PSL/mm² in GPR39 knockout mice via ex vivo autoradiography, a 27% decrease.

Animal Model:

APP/PS1 transgenic (male, 6 months old); wild-type (male, 6 months old)^[1]
Dosage:

8.5 MBq
Administration:

i.v.; single bolus injection
Result:

Reached brain uptake of 0.15 g/mL SUV in APP/PS1 mice versus 0.29 g/mL SUV in wild-type mice, representing a 46.8% decrease.

Chemical Information

Molecular Weight 409.83
Formel C₁₉H₁₆ClN₇O₂
SMILES

CC1=NN(C(N2)=C1C(C3=C(Cl)C=C(OC)C=C3)CC2=O)C4=NC=NC5=C4N=CN5
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Bhoopal B, et al. Synthesis, Radiochemistry, and Preclinical Assessment of the First GPR39 PET Imaging Agent. J Med Chem. 2026 Mar 18. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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