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Art. -Nr.: HY-175846

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TQFL13

TQFL13 is derivative of Thymoquinone (TQ) (HY-D0803) with potent anti-breast cancer activity. TQFL13 exhibits higher cytotoxicity against breast cancer cells (BT549, MDA-MB-231, 4T1). TQFL13 increases apoptosis and blocks the cell cycle at S and G2/G1 phases in breast cancer cells. TQFL13 shows dose-dependent anti-tumor efficacy in mouse breast cancer allograft model. TQFL13 can be used for the study of breast cancer.

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CAS. Nr.: 2822560-46-1
Formel: C₂₀H₂₃NO₅
Molecular Weight:357.40

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

TQFL13 Chemical Structure

CAS. Nr.: 2822560-46-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

TQFL13 (0-160 μM, 24 h) exerts cytotoxic activity against BT549, MDA-MB-231, 4T1 breast cancer cells and normal MCF-10A cells, with IC₅₀ values of 23.80 μM, 37.55 μM, 17.59 μM, and > 100 μM, respectively^[1].
TQFL13 (48 h) displays anti-viability activity against BT549, MDA-MB-231, 4T1 breast cancer cells and normal MCF-10A cells, with IC₅₀ values of 12.35 μM, 12.14 μM, 12.21 μM, and >100 μM, respectively^[1].
TQFL13 (0-20 μM, 24 h) increases apoptosis in 4 T1 cells and blocks the cell cycle at S and G2/G1 phases in BT549 and MDA-MB-231 breast cancer cells^[1].
TQFL13 (2.5-5 μM, 0-54 h) inhibits 4 T1 cell growth, migration, and invasion^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

4 T1 and MDA-MB-231 breast cancer cells
Concentration:

0, 5, 10, 20 μM
Incubation Time:

24 h
Result:

Induced the apoptosis.
Reduced the full-length PARP and BCL-2.
Increased the level of BAX.

Cell Cycle Analysis^[1]

Cell Line:

BT549 and MDA-MB-231 breast cancer cells
Concentration:

0, 5, 10, 20 μM
Incubation Time:

24 h
Result:

Blocked the cell cycle at S and G2/G1 phases.
Downregulated the level of CyclinB1, CyclinD1and p53.
Upregulated the level of phosphorylated p53 (ser15).

In Vivo

TQFL13 (3.75-15 mg/kg, i.p., starts 4 days after 4T1 cell inoculation into mammary fat pads, continues until day 30) shows anti-tumor efficacy in BALB/c mouse breast cancer allograft model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

4T1 mouse breast cancer cells were injected into the fourth mammary fat pads of female BALB/c mice to construct a breast cancer lung metastasis model ^[1]
Dosage:

3.75, 7.5, 15 mg/kg
Administration:

i.p., starts 4 days after 4T1 cell inoculation into mammary fat pads, continues until day 30
Result:

Showed dose-dependent anti-tumor efficacy.
Showed no significant changes in body weight.
Altered the morphology of breast tumor cells.
Exerted anti-tumor activity by regulating cell apoptosis and cell cycle signaling pathways.

Chemical Information

CAS. Nr. 2822560-46-1
Molecular Weight 357.40
Formel C₂₀H₂₃NO₅
SMILES

COC1=CC=C(C(OC)=C1OC)/C=N/C2=C(C(C=C(C2=O)C(C)C)=O)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wei C, et al. TQFL13, a novel synthetic derivative of thymoquinone (TQ), is more capable of inhibiting breast cancer progression than TQ. Bioorg Chem. 2025 Sep;164:108837. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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