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Art. -Nr.: HY-155954

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UCM-1336

Name: UCM-1336
Brand: MedChemExpress
SKU: HY-155954
Price: 50.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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UCM-1336 is a potent ICMT inhibitor, with an IC₅₀ of 2 μM. UCM-1336 induces mislocalization of endogenous Ras, decreases Ras activation and induces cell death by autophagy and apoptosis.

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Reinheit : 99.86%
CAS. Nr.: 1621535-90-7
Formel: C₂₆H₃₇N₃O₂
Molecular Weight:423.59

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

UCM-1336 Chemical Structure

CAS. Nr.: 1621535-90-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

HY-16160
Cysmethynil

Icmt Inhibitor

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC50: 2 μM (2 μM)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC₅₀	2 μM Compound: 3; UCM-1336	Cytotoxicity against human HL60 cells harboring N-Ras Q61K mutant assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human HL60 cells harboring N-Ras Q61K mutant assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31181882]
MDA-MB-231	IC₅₀	5 μM Compound: 3; UCM-1336	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by XTT assay Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by XTT assay	[PMID: 31181882]
MIA PaCa-2	IC₅₀	2 μM Compound: 3; UCM-1336	Cytotoxicity against human MIAPaCa2 cells harboring K-Ras G12C mutant assessed as reduction in cell viability after 72 hrs by XTT assay Cytotoxicity against human MIAPaCa2 cells harboring K-Ras G12C mutant assessed as reduction in cell viability after 72 hrs by XTT assay	[PMID: 31181882]
NIH3T3	IC₅₀	>50 μM Compound: 3; UCM-1336	Cytotoxicity against mouse NIH/3T3 cells harboring N-Ras Q61K mutant assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against mouse NIH/3T3 cells harboring N-Ras Q61K mutant assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31181882]
PANC-1	IC₅₀	7 μM Compound: 3; UCM-1336	Cytotoxicity against human PANC1 cells harboring K-Ras G12D mutant assessed as reduction in cell viability after 72 hrs by XTT assay Cytotoxicity against human PANC1 cells harboring K-Ras G12D mutant assessed as reduction in cell viability after 72 hrs by XTT assay	[PMID: 31181882]
Sf9	IC₅₀	2 μM Compound: 3; UCM-1336	Inhibition of recombinant human ICMT expressed in Sf9 insect cell membranes using biotin-farnesyl-L-cysteine as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by scintillation counting analysis Inhibition of recombinant human ICMT expressed in Sf9 insect cell membranes using biotin-farnesyl-L-cysteine as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by scintillation counting analysis	[PMID: 31181882]
SW-620	IC₅₀	3 μM Compound: 3; UCM-1336	Cytotoxicity against human SW620 cells harboring K-Ras G12V mutant assessed as reduction in cell viability after 72 hrs by XTT assay Cytotoxicity against human SW620 cells harboring K-Ras G12V mutant assessed as reduction in cell viability after 72 hrs by XTT assay	[PMID: 31181882]

Chemical Information

CAS. Nr. 1621535-90-7
Appearance Solid
Molecular Weight 423.59
Formel C₂₆H₃₇N₃O₂
Color Off-white to light yellow
SMILES

O=C(CCN(CCCCCCCC)CCC(NC1=CC=CC=C1)=O)NC2=CC=CC=C2
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (236.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3608 mL

11.8039 mL

23.6077 mL

5 mM

0.4722 mL

2.3608 mL

4.7215 mL

10 mM

0.2361 mL

1.1804 mL

2.3608 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Nagore Marín-RamosA, Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia. J Med Chem. 2019 Jul 11;62(13):6035-6046. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.3608 mL	11.8039 mL	23.6077 mL	59.0193 mL
	5 mM	0.4722 mL	2.3608 mL	4.7215 mL	11.8039 mL
	10 mM	0.2361 mL	1.1804 mL	2.3608 mL	5.9019 mL
	15 mM	0.1574 mL	0.7869 mL	1.5738 mL	3.9346 mL
	20 mM	0.1180 mL	0.5902 mL	1.1804 mL	2.9510 mL
	25 mM	0.0944 mL	0.4722 mL	0.9443 mL	2.3608 mL
	30 mM	0.0787 mL	0.3935 mL	0.7869 mL	1.9673 mL
	40 mM	0.0590 mL	0.2951 mL	0.5902 mL	1.4755 mL
	50 mM	0.0472 mL	0.2361 mL	0.4722 mL	1.1804 mL
	60 mM	0.0393 mL	0.1967 mL	0.3935 mL	0.9837 mL
	80 mM	0.0295 mL	0.1475 mL	0.2951 mL	0.7377 mL
	100 mM	0.0236 mL	0.1180 mL	0.2361 mL	0.5902 mL

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Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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CAS. Nr.:
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UCM-1336

Biologische Aktivität

Beschreibung

IC50 & Target

Cellular Effect

Chemical Information

Lösungsmittel & Löslichkeit

In Vitro:

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

UCM-1336 Related Classifications

HY-155954 Related Classifications

Bioz

Keywords

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