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Art. -Nr.: HY-N1065

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Xanthoxyletin

Xanthoxyletin is a coumarin that can be isolated from Genus Zanthoxylum and Clausena. Xanthoxyletin has antioxidant and anti-inflammatory activities. Xanthoxyletin shows cytotoxic effects to cancer cells, and induces apoptosis and necrosis. Xanthoxyletin can be used for the research of cancer and inflammation.

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CAS. Nr.: 84-99-1
Formel: C₁₅H₁₄O₄
Molecular Weight:258.27

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Xanthoxyletin Chemical Structure

CAS. Nr.: 84-99-1

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
KB	IC₅₀	133.12 μM Compound: 8	Cytotoxicity against human KB cells by resazurin microplate assay Cytotoxicity against human KB cells by resazurin microplate assay	[PMID: 21302964]
NCI-H187	IC₅₀	>200 μM Compound: 8	Cytotoxicity against human NCI-H187 by resazurin microplate assay Cytotoxicity against human NCI-H187 by resazurin microplate assay	[PMID: 21302964]
Vero	IC₅₀	>200 μM Compound: 8	Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay	[PMID: 21302964]

In Vitro

Xanthoxyletin (1-500 µM; 30 min) inhibits DPPH radical with IC₅₀ values of 247.1 μM and 63.8 μg/mL, and also shows a ferric reducing antioxidant power (FRAP) value of 45.2 µM^[2].
Xanthoxyletin (10-500 µM; 24 h) shows cytotoxicity against HepG2, HCT116 and SK-LU-1 cancer cells with IC₅₀ values of 78.2, 79.8 and 94.4 μM, respectively^[2].
Xanthoxyletin (78 and 156 μM; 12 and 24 h) induces cell apoptosis and causes low necrosis^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[2]

Cell Line:

HepG2, HCT116, SK-LU-1 and Vero cell lines
Concentration:

10-500 µM
Incubation Time:

24 hours
Result:

Exhibited cytotoxicity to HepG2, HCT116 and SK-LU-1, but showed inactive effect to Vero cells.

Apoptosis Analysis^[2]

Cell Line:

HepG2 cell line^[2]
Concentration:

78 and 156 μM
Incubation Time:

12 and 24 hours
Result:

Induced apoptosis percentage of 49.6% and 64.2% at the dose of 78 and 156 μM, respectively. Showed a better apoptosis inducing effect that cisplatin.

Chemical Information

CAS. Nr. 84-99-1
Molecular Weight 258.27
Formel C₁₅H₁₄O₄
SMILES

O=C(O1)C=CC(C1=C2)=C(OC)C3=C2OC(C)(C)C=C3
Structure Classification
- Phenylpropanoids
- Coumarins
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Sanna MD, et al. Histamine H4 receptor stimulation in the locus coeruleus attenuates neuropathic pain by promoting the coeruleospinal noradrenergic inhibitory pathway. Eur J Pharmacol. 2020 Feb 5;868:172859. [Content Brief]

[2]. Jantamat P, et al. Cytotoxicity and Apoptosis Induction of Coumarins and Carbazole Alkaloids from Clausena harmandiana. Molecules. 2019 Sep 18;24(18):3385.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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