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Cat. No.: HY-168093

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Cetzole

Cetzole is a Ferroptosis inducer. Cetzole can be used in research on non-small cell lung cancer, breast cancer, cervical cancer, colorectal cancer, and osteosarcoma.

For research use only. We do not sell to patients.

CAS No.: 3043764-86-6
Formula: C₁₁H₁₁NOS
Molecular Weight:205.28

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Cetzole Chemical Structure

CAS No.: 3043764-86-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cetzole is a Ferroptosis inducer. Cetzole can be used in research on non-small cell lung cancer, breast cancer, cervical cancer, colorectal cancer, and osteosarcoma^[1]^[2]^[3].

Cellular Effect

Cell Line	Type	Value	Description	References
HT-1080	CC₅₀	3.07 μM Compound: 1	Cytotoxicity against human HT-1080 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis Cytotoxicity against human HT-1080 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis	[PMID: 39264826]
MDA-MB-231	CC₅₀	6.28 μM Compound: 1	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis	[PMID: 39264826]
MEF	CC₅₀	2.41 μM Compound: 1	Cytotoxicity against mouse MEF cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis Cytotoxicity against mouse MEF cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis	[PMID: 39264826]
NCI-H522	CC₅₀	10.31 μM Compound: 1	Cytotoxicity against human NCI-H522 cells overexpressing GFP-tagged SLC7A11 assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis Cytotoxicity against human NCI-H522 cells overexpressing GFP-tagged SLC7A11 assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis	[PMID: 39264826]
NCI-H522	CC₅₀	2.56 μM Compound: 1	Cytotoxicity against human NCI-H522 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis Cytotoxicity against human NCI-H522 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis	[PMID: 39264826]
NCI-H522	CC₅₀	2.71 μM Compound: 1	Cytotoxicity against human NCI-H522 cells overexpressing GFP-tagged RV assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis Cytotoxicity against human NCI-H522 cells overexpressing GFP-tagged RV assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis	[PMID: 39264826]
U2OS	CC₅₀	14.9 μM Compound: 1	Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis	[PMID: 39264826]
WI-38	CC₅₀	2.51 μM Compound: 1	Cytotoxicity against human WI-38 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis Cytotoxicity against human WI-38 cells assessed as reduction in cell viability incubated for 3 days by methylene blue staining based spectrophotometric analysis	[PMID: 39264826]

In Vitro

FerroptosisAnti-cancer

Ferroptosis

Anti-cancer

9a is ten times more potent than Cetzole in inducing death in all tested cancer cell lines, and the lipid peroxidation induced by 9a shows the same trend as that induced by Cetzole^[2].

Anti-cancer

Cetzole inhibits the proliferation of NCI-H522, MDAMB231, and NARF2 cells, with IC₅₀ values of 4.54, 8.73, and 8.27 μM, respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 3043764-86-6
Appearance Solid-Liquid Mixture
Molecular Weight 205.28
Formula C₁₁H₁₁NOS
Color Brown to dark brown
SMILES

C#CC1=NC(C2=C(C)C(O)CC2)=CS1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dlamini SM. Synthesis and Biological Evaluation of Anti-cancer Agents and Identification of Their Molecular Targets (Doctoral dissertation, et al.

[2]. Mudiyanselage DS. Identification of modulators of ferroptosis and evaluation of novel chalcone/ferroptotic hybrid compounds as potential chemotherapeutic agents (Doctoral dissertation, et al.

[3]. Rodencal J, et al. A cell cycle-dependent ferroptosis sensitivity switch governed by EMP2. BioRxiv. 2023 Jul 19. [Content Brief]

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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