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Cat. No.: HY-162410

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Fluplatin

Fluplatin is a prodrug composed of cisplatin and fluvastatin. Fluplatin has antitumor activity.

For research use only. We do not sell to patients.

Formula: C₄₈H₅₆F₂N₄O₈Pt
Molecular Weight:1050.06

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Fluplatin Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Fluplatin is a prodrug composed of cisplatin and fluvastatin. Fluplatin has antitumor activity^[1].

In Vitro

The IC₅₀ values of Fluplatin against H1975, A549 and A549/DDP cells were 2.24, 4.57 and 4.51 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Fluplatin (10.49 mg/kg, tail vein injection once every three days, a total of 5 times) shows better antitumor activity in H1975 cell subcutaneous tumor model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

H1975 tumor-bearing mouse model^[1]
Dosage:

10.49 mg/kg
Administration:

Tail vein injection, once every three days, a total of 5 times
Result:

Upregulated the expression of cleaved caspase-3.
Reduced the cholesterol level in tumor tissue.

Chemical Information

Molecular Weight 1050.06
Formula C₄₈H₅₆F₂N₄O₈Pt
SMILES

FC1=CC=C(C=C1)C2=C(N(C3=C2C=CC=C3)C(C)C)/C=C/C(CC(CC(O[Pt]([NH3])(OC(CC(CC(/C=C/C4=C(C5=C(N4C(C)C)C=CC=C5)C6=CC=C(C=C6)F)O)O)=O)[NH3])=O)O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bi YY, et al. Nanoparticles targeting mutant p53 overcome chemoresistance and tumor recurrence in non-small cell lung cancer. Nat Commun. 2024 Mar 29;15(1):2759. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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Fluplatin

High-Throughput Bioactive Compound Library

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Fluplatin Related Classifications

HY-162410 Related Classifications