ELK3 - ETS transcription factor ELK3 Gene

Also Known as ERP; NET; SAP2; SAP-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2004

About ELK3

Cytogenetic location: 12q23.1 Genomic coordinates (GRCh38): 12:96,194,375-96,269,824 (from NCBI)

This gene has 6 transcripts (splice variants), 204 orthologues and 28 paralogues. Ubiquitous expression in spleen (RPKM 23.7), endometrium (RPKM 22.8) and 24 other tissues.

Summary

This gene encodes a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

ELK3 Products (8)

mRNA Protein Name
NM_001303511.2 NP_001290440.1 ETS domain-containing protein Elk-3 isoform 2
NM_001413760.1 NP_001400689.1 ETS domain-containing protein Elk-3 isoform 1
NM_001413761.1 NP_001400690.1 ETS domain-containing protein Elk-3 isoform 1
NM_001413762.1 NP_001400691.1 ETS domain-containing protein Elk-3 isoform 3
NM_001413763.1 NP_001400692.1 ETS domain-containing protein Elk-3 isoform 4
NM_001413764.1 NP_001400693.1 ETS domain-containing protein Elk-3 isoform 5
NM_001413765.1 NP_001400694.1 ETS domain-containing protein Elk-3 isoform 6
NM_005230.4 NP_005221.2 ETS domain-containing protein Elk-3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
12788937 GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
12933792 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12788937 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17474147 GOA
enables purine-rich negative regulatory element binding IDA
IDA: Inferred from direct assay
12933792 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12933792 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12788937 GOA
Cellular Component GO Annotation Evidence References Source
is active in nucleus IDA
IDA: Inferred from direct assay
12933792 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ELK3 Protein Structure

Ets

Ets: Ets-domain (5 - 86)

  • 0
  • 100
  • 200
  • 300
  • 407 a.a.
Protein Preferred Names Protein Names

ETS domain-containing protein Elk-3

  • ELK3, ETS transcription factor

ELK3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ELK3 P41970 SP4 Homo sapiens Q02446
Y2H Prey Pooling
32296183
Intra
ELK3 P41970 SP4 Homo sapiens Q02446
Validated Y2H
32296183
Intra
ELK3 P41970 SP4 Homo sapiens Q02446
Y2H Array
32296183
Intra
ELK3 P41970 PFDN5 Homo sapiens Q99471
Validated Y2H
32296183
Intra
ELK3 P41970 PFDN5 Homo sapiens Q99471
Y2H Array
32296183
Intra
ELK3 P41970 PFDN5 Homo sapiens Q99471
Y2H Prey Pooling
32296183
Intra
ELK3 P41970 LSAMP Homo sapiens Q13449
Y2H Pooling
32814053
Intra
ELK3 P41970 LSAMP Homo sapiens Q13449
Validated Y2H
32814053
Intra
ELK3 P41970 LSAMP Homo sapiens Q13449
Y2H Array
32814053
Intra
ELK3 P41970 BPIFA1 Homo sapiens Q9NP55
Y2H Array
32296183
Intra
ELK3 P41970 BPIFA1 Homo sapiens Q9NP55
Y2H Prey Pooling
32296183
Intra
ELK3 P41970 BPIFA1 Homo sapiens Q9NP55
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Yellow Nail Syndrome

  • Yns

  • Lymphedema And Yellow Nails

  • Lymphedema With Yellow Nails

  • Lymphedema-Yellow Nails

  • LYYN

  • Hereditary Lymphedema And Yellow Nails

  • Hereditary Lymphoedema And Yellow Nails
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-107753 XRP44X Inhibitor 98.09% Unkown
HY-RS04306 ELK3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07131 KCNH8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21611 Kcnh8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22155 Elk3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28129 Kcnh8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28677 Elk3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ELK3 VGNC VGNC:28433
Canis familiaris ELK3 VGNC VGNC:40304
Macaca mulatta ELK3 VGNC VGNC:72210
Felis catus ELK3 VGNC VGNC:61811
Rattus norvegicus ELK3 RGD RGD:1307764
Mus musculus ELK3 MGD MGI:101762
Others ELK3 NCBI