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Cat. No.: HY-N21573

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Milliamine A

Milliamine A is an alkaloid ingenol ester derivative and a toxic substance that can be isolated from the dried roots of Euphorbia millii Ch. des Moulins. Milliamine A induces respiratory arrest caused by circulatory system damage, ptosis, diarrhea, weakened respiration, decreased body temperature, tremors, dyspnea, clonic-tonic convulsions, hemorrhage, and congestion of the lungs and spleen in mice.

For research use only. We do not sell to patients.

CAS No.: 34391-10-1
Formula: C₄₅H₄₉N₃O₁₀
Molecular Weight:791.88

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Milliamine A Chemical Structure

CAS No.: 34391-10-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

In Vivo

Milliamine A (Compound 1) (270-2025 μg/kg; i.p.; single administration) exhibits high acute toxicity in male ICR-SLC mice, with an i.p. LD₅₀ of 0.642 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ICR-SLC (male)^[1]
Dosage:

270 μg/kg, 400 μg/kg, 600 μg/kg, 900 μg/kg, 1350 μg/kg, 2025 μg/kg
Administration:

i.p.; single injection
Result:

Exhibited an LD₅₀ of 642 μg/kg (0.642 mg/kg).
Resulted in 0/5 mortality at 270 μg/kg.
Resulted in 1/5 mortality at 400 μg/kg.
Resulted in 1/5 mortality at 600 μg/kg.
Resulted in 5/5 mortality at 900 μg/kg.
Resulted in 4/5 mortality at 1350 μg/kg.
Resulted in 5/5 mortality at 2025 μg/kg.

Chemical Information

CAS No. 34391-10-1
Molecular Weight 791.88
Formula C₄₅H₄₉N₃O₁₀
SMILES

O=C(O[C@H]1C(C)=C[C@]23[C@]1(O)[C@H](O)C(COC(C)=O)=C[C@@](C3=O)([H])[C@@]4([H])[C@@](C4(C)C)([H])C[C@H]2C)C5=CC=CC=C5NC(C6=CC=CC(O)=C6NC(C7=CC=CC=C7N(C)C)=O)=O
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Uemura, Daisuke, and Yoshimasa Hirata. The isolation and structure of toxic principles, milliamines A, B, and C, from Euphorbia Millii. Bulletin of the Chemical Society of Japan 50, no. 8 (1977): 2005-2009.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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