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NG-497

3 Cited Publications
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Based on 3 publication(s) in Google Scholar

NG-497 is a selective human adipose triglyceride lipase (ATGL) inhibitor that targets the enzymatically active patatin-like domain of human ATGL. NG-497 has potential value for tumor research.

For research use only. We do not sell to patients.

  • Purity: 99.07%
  • CAS No.: 2598242-66-9
  • Formula: C18H21NO4
  • Molecular Weight:315.36
  • Storage:

    4°C, sealed storage, away from moisture and light

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

  • NG-497 Chemical Structure
    NG-497 Chemical Structure
  • Experimental Validation Results for NG-497
  • Experimental Validation Results for NG-497
  • Experimental Validation Results for NG-497
  • Experimental Validation Results for NG-497
  • Experimental Validation Results for NG-497
CAS No.: 2598242-66-9
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609-228-6898
[email protected] [email protected]
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  • Cell Proliferation/Viability Assay
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  • RT-PCR
  • WB
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  • NG-497 Chemical Structure
    NG-497 Chemical Structure
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    NG-497 purchased from MedChemExpress. Usage Cited in: Inflammation. 2025 Jan 3. [Abstract]

    Customer Validation
     HMC3 cells were treated with NG-497 at various concentrations (0, 15.625, 31.25, 62.5, 125, 250, 500, and 1000 nM) for 24 h, and cell viability was then assessed using the CCK-8 assay.

  • 1/16

    NG-497 purchased from MedChemExpress. Usage Cited in: Inflammation. 2025 Jan 3. [Abstract]

    Customer Validation
     Representative flow cytometry histograms showing the mean fluorescence intensity (MFI) of BODIPY in LPS-stimulated HMC3 cells treated with or without 500 nM NG-497.

  • 1/16

    NG-497 purchased from MedChemExpress. Usage Cited in: Inflammation. 2025 Jan 3. [Abstract]

    Customer Validation
     Representative immunofluorescence images of BODIPY staining in LPS-stimulated HMC3 cells following treatment with or without NG-497 (500 nM).

  • 1/16

    NG-497 purchased from MedChemExpress. Usage Cited in: Inflammation. 2025 Jan 3. [Abstract]

    Customer Validation
     qPCR analysis of the expression of pro-inflammatory factors (TNF-α, IL-6, IL-1β, and CCL-2) in LPS-stimulated HMC3 cells treated with or without NG-497 (125, 250, and 500 nM).

  • 1/16

    NG-497 purchased from MedChemExpress. Usage Cited in: Inflammation. 2025 Jan 3. [Abstract]

    Customer Validation
     Western blot analysis of MTNR1A and MTNR1B expression in HMC3 cells following LPS stimulation and NG-497 pretreatment (125, 250, and 500 nM).

  • NG-497