NS3736
NS3736 is an orally effective chloride channel inhibitor that can be used for the research of osteoporosis. NS3736 targets the CIC-7 channel in osteocytes, blocks osteoclast acidification and resorption in vitro, with IC50=30 μM. In a rat model of ovariectomy-induced osteoporosis, NS3736 can enhance bone strength and bone density.
For research use only. We do not sell to patients.
- CAS No.: 265646-94-4
- Formula: C15H9BrClF3N6O
- Molecular Weight:461.62
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
CIC-7[1]
Chemical Information
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CAS No. 265646-94-4
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Molecular Weight 461.62
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Formula C15H9BrClF3N6O
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SMILES
O=C(NC1=C(C2=NN=NN2)C=C(Br)C=C1)NC3=CC=C(C(C(F)(F)F)=C3)Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)