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Siltuximab

(Synonyms: CNTO-328)
4 Cited Publications
Customer Review

Based on 4 publication(s) in Google Scholar

Siltuximab is an anti-IL-6 (interleukin-6) monoclonal antibody, and shows antitumor activity. Siltuximab can be used in Multicentric Castleman's Disease (MCD) and COVID-19 research.

For research use only. We do not sell to patients.

  • Purity: ≥99.0%
  • CAS No.: 541502-14-1
  • Molecular Weight:144.98 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Siltuximab
  • Experimental Validation Results for Siltuximab
  • Experimental Validation Results for Siltuximab
  • Experimental Validation Results for Siltuximab
  • Experimental Validation Results for Siltuximab
  • Siltuximab Chemical Structure
    Siltuximab Chemical Structure
CAS No.: 541502-14-1
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Siltuximab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Publications Citing Use of MedChemExpress (MCE) Siltuximab

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Customer Validation & Images
Cell Imaging/StainingIF
  • Cell Imaging/Staining
  • IF

All Interleukin Related Isoforms

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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized IL-6 Protein, Human (HY-P7044) can bind Siltuximab. The EC50 for this effect is 4.04 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5×106 Siha cells with Siltuximab (HY-P9956, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Siltuximab purchased from MedChemExpress. Usage Cited in: ACS Nano. 2025 Sep 16;19(36):32361-32373. [Abstract]

    Customer Validation
     Representative images of fibrosis-induced spheroids subjected to microfluidic deformation analysis, comparing untreated control, antifibrotic drug NTD, and anti-interleukin drugs TCZ, STX, DUP, and TRA. Mab (5 μg/mL, 1 d) were added, Scale bars indicate 100 μm.

  • 1/16

    Siltuximab purchased from MedChemExpress. Usage Cited in: ACS Nano. 2025 Sep 16;19(36):32361-32373. [Abstract]

    Customer Validation
     Confocal fluorescence images showing the expression of collagen-1 and α-SMA in spheroids treated with NTD, TCZ, STX, DUP, and TRA. Mab (5 μg/mL, 1 d) were added, Scale bars indicate 100 μm.

  • Siltuximab Chemical Structure
    1/16
  • Siltuximab
  • Immobilized IL-6 Protein, Human (HY-P7044) can bind Siltuximab. The EC50 for this effect is 4.04 ng/mL.
  • Flow cytometric analysis of 1.5×106 Siha cells with Siltuximab (HY-P9956, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).