2. Anti-infection
  3. SARS-CoV
  4. Obeldesivir

Obeldesivir  (Synonyms: ATV006)

Cat. No.: HY-145994 Purity: 99.41%
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Obeldesivir (ATV006) is a potent, orally active antiviral agent and ester proagents of GS-441524. Obeldesivir inhibits the replication of SARS-CoV-2 and its variants. Obeldesivir can be used for SARS-CoV-2 research.

For research use only. We do not sell to patients.

Obeldesivir Chemical Structure

Obeldesivir Chemical Structure

CAS No. : 2647441-36-7

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5 mg USD 300 In-stock
10 mg USD 480 In-stock
25 mg USD 950 In-stock
50 mg USD 1450 In-stock
100 mg USD 2250 In-stock
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Based on 1 publication(s) in Google Scholar

Obeldesivir Related Antibodies

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  • Purity & Documentation

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Description

Obeldesivir (ATV006) is a potent, orally active antiviral agent and ester proagents of GS-441524. Obeldesivir inhibits the replication of SARS-CoV-2 and its variants. Obeldesivir can be used for SARS-CoV-2 research[1].

In Vitro

Obeldesivir (0.001-100 μM; 48 h; Vero E6 cells) inhibits the replication of authentic SARS-CoV-2 and its variants of concern. Obeldesivir has an overall >4-fold and >12-fold potency improvement in inhibiting the replication of Delta and Omicron variants, with EC50 values of 0.349 μM and 0.106 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Obeldesivir Related Antibodies
In Vivo

Obeldesivir (5-25 mg/kg; p.o. and i.v.; Sprague Dawley rats) has favorable pharmacokinetic profiles in rats with high oral bioavailability (F %) of 81.5% and maximum blood concentration (Cmax) of 8.2 μM[1].
Obeldesivir (250-500 mg/kg; p.o.; daily, for 4 days; hACE2 knock-in and Ad5-hACE2 mice) has antiviral activity and inhibits SARS-CoV-2 replication in mouse models[1].
Obeldesivir (100-250 mg/kg; p.o.; daily, for 10 days) reduces lung damage and protects K18-hACE2 mice[1].
Obeldesivir (10-150 mg/kg; p.o.; daily, for 3 days) reduces virus titers and lung damage caused by Delta variant infection in K18-hACE2 mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague Dawley rats[1]
Dosage: 5 and 25 mg/kg
Administration: Oral administration (25 mg/kg) and intravenous injection (5 mg/kg)
Result: 1.19
parameters i.v. (5 mg/kg) p.o. (25 mg/kg)
AUClast (μM·h) 5.6 22.8
T1/2 (h) 1.5 1.2
Tmax (h) 0.5
Cmax (μM) 8.7 8.2
F % 81.5
Animal Model: hACE2 knock-in and Ad5-hACE2 mice[1]
Dosage: 250 and 500 mg/kg
Administration: Oral administration; daily, for 4 days
Result: Inhibited gRNA and sgRNA, which is Biomarkers of coronavirus replication. Reduced the viral load and pathological damage of the lung.
Animal Model: K18-hACE2 mice[1]
Dosage: 100 and 250 mg/kg
Administration: Oral administration; daily, for 10 days
Result: Reduced viral RNA and increased the survival rate of mice. Reduced evidence of lung pathology and the production of inflammatory cytokines and chemokines in the lung tissues.
Animal Model: K18-hACE2 mice[1]
Dosage: 10, 30, 80 and 150 mg/kg
Administration: Oral administration; daily, for 3 days
Result: Reduced viral load in a dose-dependent manner and alleviated the symptoms in the lung.
Clinical Trial
Molecular Weight

361.35

Formula

C16H19N5O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N#C[C@@]1(C2=CC=C3N2N=CN=C3N)O[C@@H]([C@H]([C@H]1O)O)COC(C(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (691.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7674 mL 13.8370 mL 27.6740 mL
5 mM 0.5535 mL 2.7674 mL 5.5348 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7674 mL 13.8370 mL 27.6740 mL 69.1850 mL
5 mM 0.5535 mL 2.7674 mL 5.5348 mL 13.8370 mL
10 mM 0.2767 mL 1.3837 mL 2.7674 mL 6.9185 mL
15 mM 0.1845 mL 0.9225 mL 1.8449 mL 4.6123 mL
20 mM 0.1384 mL 0.6918 mL 1.3837 mL 3.4592 mL
25 mM 0.1107 mL 0.5535 mL 1.1070 mL 2.7674 mL
30 mM 0.0922 mL 0.4612 mL 0.9225 mL 2.3062 mL
40 mM 0.0692 mL 0.3459 mL 0.6918 mL 1.7296 mL
50 mM 0.0553 mL 0.2767 mL 0.5535 mL 1.3837 mL
60 mM 0.0461 mL 0.2306 mL 0.4612 mL 1.1531 mL
80 mM 0.0346 mL 0.1730 mL 0.3459 mL 0.8648 mL
100 mM 0.0277 mL 0.1384 mL 0.2767 mL 0.6918 mL
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Obeldesivir Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Obeldesivir2647441-36-7ATV006ATV 006ATV-006SARS-CoVSARS coronaviruspodrugsantiviralSARS-CoV-2Vero E6 cellsviral loadRNAInhibitorinhibitorinhibit

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