ATX-IN-3
ATX-IN-3 is an orally active autotaxin (ATX) inhibitor with an IC50 of 46 nM. ATX-IN-3 certainly reduces collagen deposition and ameliorates lung fibrosis in the pulmonary fibrosis mouse model. ATX-IN-3 has good metabolic stability and drug-like properties. ATX-IN-3 can used for the study of idiopathic pulmonary fibrosis (IFP).
For research use only. We do not sell to patients.
- Formula: C29H27FN6O3
- Molecular Weight:526.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
ATX-IN-3 (Compound 12) endows with promising drug-like properties including favorable metabolic stability (t1/2 = 73.06 min, Clint = 18.97 μL/min/mg) in rat liver microsomes, greatly drug-likeness score (1.24) and ligand lipophilicity efficiency (LLE) value (2.98) [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Bleomycin induced IPF model established in male C57BL/6 mice (6-8 weeks)[1]
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Dosage:60 mg/kg
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Administration:Oral gavage (i.g.), once daily for 21 days
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Result:Significantly improved fibrosis indicators, reduced collagen deposition and inflammatory infiltration. Did not change heart, liver, and kidney indexes, and ALT, AST and other indicators are all within the normal range.
Chemical Information
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Molecular Weight 526.56
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Formula C29H27FN6O3
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SMILES
FC1=CC=C(C(N2CC(N3CCC(C4=NC5=C(C=CC(NC(C6=CC=CO6)=O)=C5)N4)CC3)(CC#N)C2)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ATX-IN-3 Related Classifications
HY-175537 Related Classifications
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