ATX-IN-3
ATX-IN-3 is an orally active autotaxin (ATX) inhibitor with an IC50 of 46 nM. ATX-IN-3 certainly reduces collagen deposition and ameliorates lung fibrosis in the pulmonary fibrosis mouse model. ATX-IN-3 has good metabolic stability and drug-like properties. ATX-IN-3 can used for the study of idiopathic pulmonary fibrosis (IFP).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C29H27FN6O3
- Molecular Weight:526.56
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
ATX-IN-3 (Compound 12) endows with promising drug-like properties including favorable metabolic stability (t1/2 = 73.06 min, Clint = 18.97 μL/min/mg) in rat liver microsomes, greatly drug-likeness score (1.24) and ligand lipophilicity efficiency (LLE) value (2.98) [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Bleomycin induced IPF model established in male C57BL/6 mice (6-8 weeks)[1]
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Dosage:60 mg/kg
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Administration:Oral gavage (i.g.), once daily for 21 days
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Result:Significantly improved fibrosis indicators, reduced collagen deposition and inflammatory infiltration. Did not change heart, liver, and kidney indexes, and ALT, AST and other indicators are all within the normal range.
Chemical Information
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Molecular Weight 526.56
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Formel C29H27FN6O3
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SMILES
FC1=CC=C(C(N2CC(N3CCC(C4=NC5=C(C=CC(NC(C6=CC=CO6)=O)=C5)N4)CC3)(CC#N)C2)=O)C=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
ATX-IN-3 Related Classifications
HY-175537 Related Classifications
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