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Cat. No.: HY-N14422

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Collismycin B

Collismycin B is a potent dexamethasone-glucocorticoid receptor inhibitor with an IC₅₀ value of 10 µM. Collismycin B shows antimicrobial activity. Collismycin B shows cytotoxicity.

For research use only. We do not sell to patients.

CAS No.: 158792-25-7
Formula: C₁₃H₁₃N₃O₂S
Molecular Weight:275.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Collismycin B Chemical Structure

CAS No.: 158792-25-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Collismycin B is a potent dexamethasone-glucocorticoid receptor inhibitor with an IC₅₀ value of 10 µM. Collismycin B shows antimicrobial activity. Collismycin B shows cytotoxicity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	107 μM Compound: 4, SF2738B	Cytotoxicity against human HCT116 cells assessed as inhibition of cell proliferation Cytotoxicity against human HCT116 cells assessed as inhibition of cell proliferation	[PMID: 21873059]

Chemical Information

CAS No. 158792-25-7
Molecular Weight 275.33
Formula C₁₃H₁₃N₃O₂S
SMILES

O/N=C\C1=NC(C2=CC=CC=N2)=CC(OC)=C1SC
Structure Classification
- Alkaloids
- Pyridine Alkaloids
Initial Source
- Microorganisms
Streptomyces sp. MC025
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shindo K, et al. Collismycins A and B, novel non-steroidal inhibitors of dexamethasone-glucocorticoid receptor binding. J Antibiot (Tokyo). 1994 Sep;47(9):1072-4. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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