GZMK - granzyme K Gene

Also Known as TRYP2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3003

About GZMK

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:55,024,256-55,034,570 (from NCBI)

This gene has 2 transcripts (splice variants), 116 orthologues and 5 paralogues. Biased expression in lymph node (RPKM 65.9), spleen (RPKM 22.6) and 7 other tissues.

Summary

This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from Infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in Other granzymes. [provided by RefSeq, Jul 2008]

GZMK Products (1)

mRNA Protein Name
NM_002104.3 NP_002095.1 granzyme K precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables serine-type endopeptidase activity IDA
IDA: Inferred from direct assay
10480954 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GZMK Protein Structure

Trypsin

Trypsin: Trypsin (27 - 254)

  • 0
  • 100
  • 200
  • 264 a.a.
Protein Preferred Names Protein Names

granzyme K

  • NK-Tryp-2

GZMK Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GZMK P49863 TMBIM6 Homo sapiens P55061
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

GZMK Antibodies

Cat. No. Product Name Application Reactivity
HY-P84360 GZMK Antibody (YA4057) IHC-P, FC, ELISA Human
HY-P84360A GZMK Antibody (YA4057)(PBS only) IHC-P, FC, ELISA Human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-122542B PPACK TFA Inhibitor 99.80% Unkown
HY-122542A PPACK dihydrochloride Inhibitor 99.07% Unkown
HY-RS05942 GZMK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-122542 PPACK Inhibitor / Unkown
HY-RS20283 Gzmk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26791 Gzmk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GZMK VGNC VGNC:67528
Rattus norvegicus GZMK RGD RGD:68401
Canis familiaris GZMK VGNC VGNC:41578
Bos taurus GZMK VGNC VGNC:29733
Macaca mulatta GZMK VGNC VGNC:73339
Mus musculus GZMK MGD MGI:1298232
Others GZMK NCBI