PD 135158
PD 135158 (CAM 1028) is a selective CCKB receptor antagonist with an IC50 of 2.8 nM against mouse cortex CCKB. PD 135158 shows anxiolytic activity.
For research use only. We do not sell to patients.
- CAS No.: 130325-35-8
- Formula: C42H61N5O11
- Molecular Weight:811.96
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CCKBR 2.8 nM (IC50) |
CCKAR 1232 nM (IC50) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley rats, conditioned suppression of drinking procedure model[2]
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Dosage:0.001, 0. 01, and 0.1 mg/kg
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Administration:0.2 mL/kg SC 30 min before prexposure and conditioning
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Result:Elicited a clear latent inhibition effect under conditions that did not lead to latent inhibition in control rats.
Chemical Information
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CAS No. 130325-35-8
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Molecular Weight 811.96
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Formula C42H61N5O11
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SMILES
C[C@@](C1(C)C)(CC[C@@]1([H])C2)[C@@H]2OC(N[C@](C(NC[C@@H](C3=CC=CC=C3)NC(CCC(O)=O)=O)=O)(C)CC4=CNC5=CC=CC=C45)=O.O[C@H]([C@@H](O)CNC)[C@H](O)[C@H](O)CO
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Synonyms
CAM 1028
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Hughes J, et al. Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity. Proc Natl Acad Sci U S A. 1990 Sep;87(17):6728-32. [Content Brief]
[2]. Gracey DJ, et al. PD-135,158, a cholecystokinin(B) antagonist, enhances latent inhibition in the rat. Pharmacol Biochem Behav. 2000 Mar;65(3):459-63. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PD 135158 Related Classifications
HY-129810 Related Classifications
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