2. Others Antibody-drug Conjugate/ADC Related Cytoskeleton Cell Cycle/DNA Damage
  3. Microtubule/Tubulin ADC Payload Isotope-Labeled Compounds
  4. Auristatin E-d8

Auristatin E-d8 is the deuterium labeled Auristatin E (HY-15582). Auristatin E is a cytotoxic microtubule polymerization inhibitor with potent and selective antitumor activity. Auristatin E is a cytotoxin in antibody-drug conjugates (ADC). Auristatin E inhibits cell division by blocking the polymerisation of tubulin, promising for research in B-cell malignancies. Auristatin E, a synthetic analogue of the Dolastatin 10 (HY-15580), is linear peptides comprised of four amino acids.

For research use only. We do not sell to patients.

Auristatin E-d<sub>8</sub>

Auristatin E-d8 Chemical Structure

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Auristatin E-d8:

Auristatin E-d8 Related Antibodies

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Description

Auristatin E-d8 is the deuterium labeled Auristatin E (HY-15582). Auristatin E is a cytotoxic microtubule polymerization inhibitor with potent and selective antitumor activity. Auristatin E is a cytotoxin in antibody-drug conjugates (ADC). Auristatin E inhibits cell division by blocking the polymerisation of tubulin, promising for research in B-cell malignancies. Auristatin E, a synthetic analogue of the Dolastatin 10 (HY-15580), is linear peptides comprised of four amino acids[1][2][3].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Auristatin E-d8 Related Antibodies
Molecular Weight

740.05

Formula

C40H61D8N5O7
Unlabeled CAS
Appearance

Solid

Color

White to off-white

SMILES

CC(C)[C@H](N(C)C)C(NC(C(N([C@@H]([C@@H](C)CC)[C@@H](CC(N1CCC[C@@]1([H])[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C2=CC=CC=C2)O)=O)=O)OC)C)=O)([2H])C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (135.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3513 mL 6.7563 mL 13.5126 mL
5 mM 0.2703 mL 1.3513 mL 2.7025 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3513 mL 6.7563 mL 13.5126 mL 33.7815 mL
5 mM 0.2703 mL 1.3513 mL 2.7025 mL 6.7563 mL
10 mM 0.1351 mL 0.6756 mL 1.3513 mL 3.3782 mL
15 mM 0.0901 mL 0.4504 mL 0.9008 mL 2.2521 mL
20 mM 0.0676 mL 0.3378 mL 0.6756 mL 1.6891 mL
25 mM 0.0541 mL 0.2703 mL 0.5405 mL 1.3513 mL
30 mM 0.0450 mL 0.2252 mL 0.4504 mL 1.1261 mL
40 mM 0.0338 mL 0.1689 mL 0.3378 mL 0.8445 mL
50 mM 0.0270 mL 0.1351 mL 0.2703 mL 0.6756 mL
60 mM 0.0225 mL 0.1126 mL 0.2252 mL 0.5630 mL
80 mM 0.0169 mL 0.0845 mL 0.1689 mL 0.4223 mL
100 mM 0.0135 mL 0.0676 mL 0.1351 mL 0.3378 mL
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Auristatin E-d8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Auristatin E-d8Microtubule/TubulinADC PayloadIsotope-Labeled CompoundsADC CytotoxinInhibitorinhibitorinhibit

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Auristatin E-d8
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HY-15582S
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