Azalamellarin N
Based on 2 publication(s) in Google Scholar
Azalamellarin N is an inhibitor of pyroptosis and has different inhibitory effects on different pyroptosis inducers. Azalamellarin N inhibits pyroptosis by targeting molecules that act upstream of NLRP3 inflammasome activation, rather than directly targeting components of the NLRP3 inflammasome. Inhibitory potency against different pyroptosis inducers: Nigericin (HY-127019) > R837 (HY-B0180).
For research use only. We do not sell to patients.
- Purity: 99.58%
- CAS No.: 1809535-57-6
- Formula: C28H22N2O7
- Molecular Weight:498.48
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Azalamellarin N
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.0155 μM
Compound: 5
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Cytotoxicity against human A549 cells harboring wild type EGFR assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human A549 cells harboring wild type EGFR assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 33556869] |
| NCI-H1975 | IC50 |
0.0019 μM
Compound: 5
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Cytotoxicity against human NCI-H1975 cells harboring T790M/L858R mutant assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human NCI-H1975 cells harboring T790M/L858R mutant assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 33556869] |
Azalamellarin N (0.125-1 μM, pretreated 30 min) attenuates ATP- and nigericin-induced pyroptosis and activation of the NLRP3 inflammasome[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:THP-1, J774.1
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Concentration:0.125, 0.25, 0.5, 1 μM
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Incubation Time:pretreated 30 min
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Result:Strongly inhibited ATP- and nigericin-induced IL-1β release, but only modestly inhibited R837-induced IL-1β release.
Inhibited Nigericin-induced cleavage of caspase-1.
Suppressed ATP-induced oligomerization of ASC to a similar extent to MCC950.
Chemical Information
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CAS No. 1809535-57-6
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Appearance Solid
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Molecular Weight 498.48
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Formula C28H22N2O7
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Color White to off-white
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SMILES
OC1=CC(C2=C(C(C=C(OC)C(O)=C3)=C3C=C4)N4C5=C2C6=C(C=C(O)C(OC)=C6)NC5=O)=CC=C1OC
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Synonyms
AZL-N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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J Colloid Interface Sci
Photoactive metal-covalent organic framework nanozymes with enhanced peroxidase-mimicking activity for eliminating drug-resistant bacterial infections. [Abstract]2025 Jun 12;699(Pt 1):138178. PMID: 40527142 -
Cent Eur J Immunol
Inhibition of XPOT promotes breast cancer cell pyroptosis to suppress cancer progression. [Abstract]2025;50(3):248-259. PMID: 41438360
Purity & Documentation
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Data Sheet (281 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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