Azido-PEG16-NHS ester
Based on 1 Customer Validation
Azido-PEG16-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG16-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
For research use only. We do not sell to patients.
- Purity: 99.90%
- CAS No.: 2553413-74-2
- Formula: C39H72N4O20
- Molecular Weight:917.00
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
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PEGs |
Alkyl/ether |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2553413-74-2
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Appearance Liquid
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Molecular Weight 917.00
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Formula C39H72N4O20
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Color Colorless to light yellow
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SMILES
O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : ≥ 125 mg/mL (136.31 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0905 mL | 5.4526 mL | 10.9051 mL | 27.2628 mL |
| 5 mM | 0.2181 mL | 1.0905 mL | 2.1810 mL | 5.4526 mL | |
| 10 mM | 0.1091 mL | 0.5453 mL | 1.0905 mL | 2.7263 mL | |
| 15 mM | 0.0727 mL | 0.3635 mL | 0.7270 mL | 1.8175 mL | |
| 20 mM | 0.0545 mL | 0.2726 mL | 0.5453 mL | 1.3631 mL | |
| 25 mM | 0.0436 mL | 0.2181 mL | 0.4362 mL | 1.0905 mL | |
| 30 mM | 0.0364 mL | 0.1818 mL | 0.3635 mL | 0.9088 mL | |
| 40 mM | 0.0273 mL | 0.1363 mL | 0.2726 mL | 0.6816 mL | |
| 50 mM | 0.0218 mL | 0.1091 mL | 0.2181 mL | 0.5453 mL | |
| 60 mM | 0.0182 mL | 0.0909 mL | 0.1818 mL | 0.4544 mL | |
| 80 mM | 0.0136 mL | 0.0682 mL | 0.1363 mL | 0.3408 mL | |
| 100 mM | 0.0109 mL | 0.0545 mL | 0.1091 mL | 0.2726 mL |
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