2. PROTAC
  3. PROTAC Linkers
  4. Azido-PEG6-azide

Azido-PEG6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

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Azido-PEG6-azide Chemical Structure

Azido-PEG6-azide Chemical Structure

CAS No. : 1243536-56-2

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Based on 1 publication(s) in Google Scholar

Azido-PEG6-azide Related Antibodies

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Description

Azido-PEG6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Azido-PEG6-azide Related Antibodies
Molecular Weight

376.41

Formula

C14H28N6O6
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[N-]=[N+]=NCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (265.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6567 mL 13.2834 mL 26.5668 mL
5 mM 0.5313 mL 2.6567 mL 5.3134 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6567 mL 13.2834 mL 26.5668 mL 66.4169 mL
5 mM 0.5313 mL 2.6567 mL 5.3134 mL 13.2834 mL
10 mM 0.2657 mL 1.3283 mL 2.6567 mL 6.6417 mL
15 mM 0.1771 mL 0.8856 mL 1.7711 mL 4.4278 mL
20 mM 0.1328 mL 0.6642 mL 1.3283 mL 3.3208 mL
25 mM 0.1063 mL 0.5313 mL 1.0627 mL 2.6567 mL
30 mM 0.0886 mL 0.4428 mL 0.8856 mL 2.2139 mL
40 mM 0.0664 mL 0.3321 mL 0.6642 mL 1.6604 mL
50 mM 0.0531 mL 0.2657 mL 0.5313 mL 1.3283 mL
60 mM 0.0443 mL 0.2214 mL 0.4428 mL 1.1069 mL
80 mM 0.0332 mL 0.1660 mL 0.3321 mL 0.8302 mL
100 mM 0.0266 mL 0.1328 mL 0.2657 mL 0.6642 mL
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Azido-PEG6-azide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Azido-PEG6-azide1243536-56-2PROTAC LinkersInhibitorinhibitorinhibit

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