B3GNT2-IN-1
Based on 1 Customer Validation
B3GNT2-IN-1 is a β-1,3-N-acetylglucosaminyltransferase 2 (B3GNT2) inhibitor with an IC50 of 0.009 μM. B3GNT2-IN-1 is applicable to research related to rheumatoid arthritis, ankylosing spondylitis and psoriasis.
For research use only. We do not sell to patients.
- Purity: 99.56%
- CAS No.: 3033557-95-5
- Formula: C22H23F3N6O2
- Molecular Weight:460.45
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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B3GNT2 0.009 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Jurkat | IC50 |
1.1 μM
Compound: 8j
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Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth incubated for 3 days by SYTOX blue staining based flow cytometry analysis
Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth incubated for 3 days by SYTOX blue staining based flow cytometry analysis
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[PMID: 37988652] |
B3GNT2-IN-1 (Compound 8j) inhibits purified B3GNT2 enzyme with an IC50 of 0.009 μM, and exerts no significant inhibitory effect on purified B3GNT4 enzyme[1].
B3GNT2-IN-1 inhibits B3GNT2-dependent poly-N-acetyllactosamine production in Jurkat cells, with an IC50 of 1.1 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3033557-95-5
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Appearance Solid
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Molecular Weight 460.45
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Formula C22H23F3N6O2
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Color White to off-white
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SMILES
O=C1NC2=CC=C(C=C2N1[C@@H](C(C)(C)C)C)C(N[C@@](C3=CN=C(N=C3)C(F)(F)F)4C)=NC4=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (217.18 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1718 mL | 10.8589 mL | 21.7179 mL | 54.2947 mL |
| 5 mM | 0.4344 mL | 2.1718 mL | 4.3436 mL | 10.8589 mL | |
| 10 mM | 0.2172 mL | 1.0859 mL | 2.1718 mL | 5.4295 mL | |
| 15 mM | 0.1448 mL | 0.7239 mL | 1.4479 mL | 3.6196 mL | |
| 20 mM | 0.1086 mL | 0.5429 mL | 1.0859 mL | 2.7147 mL | |
| 25 mM | 0.0869 mL | 0.4344 mL | 0.8687 mL | 2.1718 mL | |
| 30 mM | 0.0724 mL | 0.3620 mL | 0.7239 mL | 1.8098 mL | |
| 40 mM | 0.0543 mL | 0.2715 mL | 0.5429 mL | 1.3574 mL | |
| 50 mM | 0.0434 mL | 0.2172 mL | 0.4344 mL | 1.0859 mL | |
| 60 mM | 0.0362 mL | 0.1810 mL | 0.3620 mL | 0.9049 mL | |
| 80 mM | 0.0271 mL | 0.1357 mL | 0.2715 mL | 0.6787 mL | |
| 100 mM | 0.0217 mL | 0.1086 mL | 0.2172 mL | 0.5429 mL |
B3GNT2-IN-1 Related Classifications
HY-149777 Related Classifications
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