Beclin1-Bcl-2 interaction inhibitor 1
Beclin1-Bcl-2 interaction inhibitor 1 is a Beclin1 and Bcl-2 interaction inhibitor with an IC50 value of 4.4 nM. Beclin1-Bcl-2 interaction inhibitor 1 disrupts the binding of the Bcl-2-Beclin 1 BH3 domain. Beclin1-Bcl-2 interaction inhibitor 1 can be used in the research of cancer and neurodegenerative diseases.
For research use only. We do not sell to patients.
- Formula: C26H24BrN3O3
- Molecular Weight:506.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Beclin1-Bcl-2 interaction inhibitor 1 (compound 35) potently and selectively inhibits the interaction between the Beclin 1 BH3 domain and full cytoplasmic Bcl-2(1-218) with an IC50 of 4.4 nM, showing 200-fold greater potency for this interaction compared to inhibiting Bax BH3/Bcl-2 binding[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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Molecular Weight 506.39
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Formula C26H24BrN3O3
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SMILES
[H][C@]1(CC(C2=CC=C(NC(OC(C)C)=O)C=C2)=NN1C(C3=CC=C(Br)C=C3)=O)C4=CC=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Beclin1-Bcl-2 interaction inhibitor 1 Related Classifications
HY-149681 Related Classifications
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