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Cat. No.: HY-13567A

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Bendamustine hydrochloride hydrate

(Synonyms: SDX-105 hydrate)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Bendamustine hydrochloride hydrate (SDX-105 hydrate), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride hydrate activates DNA-damage stress response and apoptosis. Bendamustine hydrochloride hydrate has potent alkylating, anticancer and antimetabolite properties.

For research use only. We do not sell to patients.

CAS No.: 1374784-02-7
Formula: C₁₆H₂₄Cl₃N₃O₃
Molecular Weight:412.74

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Bendamustine hydrochloride hydrate Chemical Structure

CAS No.: 1374784-02-7

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Description

Chemical Information

CAS No. 1374784-02-7
Molecular Weight 412.74
Formula C₁₆H₂₄Cl₃N₃O₃
SMILES

O=C(CCCC1=NC2=C(N1C)C=CC(N(CCCl)CCCl)=C2)O.Cl.O
Synonyms

SDX-105 hydrate
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Leukemia

del(8p) and TNFRSF10B loss are associated with a poor prognosis and resistance to fludarabine in chronic lymphocytic leukemia. [Abstract]

2023 Nov;37(11):2221-2230. PMID: 37752286

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Leoni LM, et al. Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents. Clin Cancer Res. 2008 Jan 1;14(1):309-17. [Content Brief]

[2]. Cives M, et al. Bendamustine overcomes resistance to melphalan in myeloma cell lines by inducing cell death through mitotic catastrophe. Cell Signal. 2013 May;25(5):1108-17. [Content Brief]

[3]. Ackler S, et al. Navitoclax (ABT-263) and bendamustine ± rituximab induce enhanced killing of non-Hodgkin's lymphoma tumours in vivo. Br J Pharmacol. 2012 Oct;167(4):881-91. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Bendamustine hydrochloride hydrate

1 Cited Publications

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Bendamustine hydrochloride hydrate

Publications Citing Use of MedChemExpress (MCE) Bendamustine hydrochloride hydrate

Biological Activity

Chemical Information

Publications (1)

Purity & Documentation

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Bendamustine hydrochloride hydrate Related Classifications

HY-13567A Related Classifications