Biotin-PEG2-C6-azide
Based on 1 Customer Validation
Biotin-PEG2-C6-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTAC. Biotin-PEG2-C6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
For research use only. We do not sell to patients.
- Purity: 95.87%
- CAS No.: 1011268-29-3
- Formula: C22H39N7O5S
- Molecular Weight:513.65
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
All PROTAC Linkers Isoforms
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Biological Activity
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PEGs |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1011268-29-3
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Appearance Solid
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Molecular Weight 513.65
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Formula C22H39N7O5S
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Color White to off-white
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SMILES
O=C(NCCOCCOCCNC(CCCCCN=[N+]=[N-])=O)CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (194.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (241 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9469 mL | 9.7343 mL | 19.4685 mL | 48.6713 mL |
| 5 mM | 0.3894 mL | 1.9469 mL | 3.8937 mL | 9.7343 mL | |
| 10 mM | 0.1947 mL | 0.9734 mL | 1.9469 mL | 4.8671 mL | |
| 15 mM | 0.1298 mL | 0.6490 mL | 1.2979 mL | 3.2448 mL | |
| 20 mM | 0.0973 mL | 0.4867 mL | 0.9734 mL | 2.4336 mL | |
| 25 mM | 0.0779 mL | 0.3894 mL | 0.7787 mL | 1.9469 mL | |
| 30 mM | 0.0649 mL | 0.3245 mL | 0.6490 mL | 1.6224 mL | |
| 40 mM | 0.0487 mL | 0.2434 mL | 0.4867 mL | 1.2168 mL | |
| 50 mM | 0.0389 mL | 0.1947 mL | 0.3894 mL | 0.9734 mL | |
| 60 mM | 0.0324 mL | 0.1622 mL | 0.3245 mL | 0.8112 mL | |
| 80 mM | 0.0243 mL | 0.1217 mL | 0.2434 mL | 0.6084 mL | |
| 100 mM | 0.0195 mL | 0.0973 mL | 0.1947 mL | 0.4867 mL |
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