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Cat. No.: HY-W134328B

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Blue dextran (MW 10000)

(Synonyms: Dextran blue (MW 10000))

Blue dextran (Dextran blue) (MW 10000) is a 10 kDa osmotic dextran. Blue dextran (MW 10000) penetrates all sublayers of the pre-epithelial mucus gel layer in the rat distal colon and is taken up by the nuclei of surface cells in the rat distal colonic mucosa. Blue dextran (MW 10000) is not blocked by the pre-epithelial mucus gel layer of the rat distal colon, which acts as a diffusion barrier.

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CAS No.: 87915-38-6
Masse moléculaire:10000 (Average)

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Blue dextran (MW 10000) Chemical Structure

CAS No.: 87915-38-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- In Vivo
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Description

In Vitro

Blue dextran (MW 10000) (Dextran blue (MW 10000)) is a conjugate formed by the binding of dextran to the Cibacron Blue 3G-A ligand, and is mainly used for the purification of human serum albumin^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Blue dextran (MW 10000) (10 mg/mL; intraluminally into distal colon segments) traverses the 30-50 μm thick pre-epithelial mucus gel layer of the rat distal colon and enters superficial mucosal cells in less than 1 minute, demonstrating no barrier effect from the PML^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar AS/Ztm; Lewis (adult, both sexes, mean body weight 302 ± 52 g)^[2]
Dosage:

10 mg/mL (200 μl total volume)
Administration:

intraluminally into distal colon segments
Result:

Traversed the 30-50 μm thick pre-epithelial mucus gel layer and was present in the nuclei of superficial distal colonic mucosal cells at 1 minute after administration.
Was homogeneously distributed throughout all pre-epithelial mucus gel layer sublayers and present in most superficial mucosal cells at 2 minutes after administration.
Remained distributed across all pre-epithelial mucus gel layer sublayers and was present in superficial mucosal cells at 10 minutes after administration.

Chemical Information

CAS No. 87915-38-6
Masse moléculaire 10000 (Average)
SMILES

[Blue dextran (MW 10000)]
Synonyms

Dextran blue (MW 10000)
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Cserr HF, et al. Bulk flow of interstitial fluid after intracranial injection of blue dextran 2000. Exp Neurol. 1974 Oct;45(1):50-60. [Content Brief]

[2]. Szentkuti L. Light microscopical observations on luminally administered dyes, dextrans, nanospheres and microspheres in the pre-epithelial mucus gel layer of the rat distal colon[J]. Journal of Controlled Release, 1997, 46(3): 233-242.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Blue dextran (MW 10000)

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DEAE-dextran (MW 40000)

Dextran T10 (MW 10,000)

Dextran T60 (MW 60,000)

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Chemical Information

Pureté et documentation

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Calculators

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Bioz

Blue dextran (MW 10000)

Blue dextran (MW 2000000)

Blue dextran (MW 5000)

Blue dextran (MW 20000)

DEAE-dextran (MW 500000)

Blue dextran (MW 70000)

Dextran T500 (MW 500,000)

Dextran T70 (MW 70,000)

Dextran

DEAE-dextran (MW 40000)

Dextran T10 (MW 10,000)

Dextran T60 (MW 60,000)

Dextran (MW 40000)

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Blue dextran (MW 10000) Related Classifications

HY-W134328B Related Classifications

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