Bromo-PEG1-C2-azide
Based on 1 Customer Validation
Bromo-PEG1-C2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromo-PEG1-C2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.45%
- CAS 番号: 1144106-65-9
- 分子式: C4H8BrN3O
- 分子量:194.03
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保管条件:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
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- 純度とドキュメンテーション
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Help & FAQs
PROTAC Linkers アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
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PEGs |
体外実験
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1144106-65-9
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性状 Liquid
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分子量 194.03
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分子式 C4H8BrN3O
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Color Colorless to light yellow
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SMILES
BrCCOCCN=[N+]=[N-]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : ≥ 350 mg/mL (1803.84 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (267 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.1538 mL | 25.7692 mL | 51.5384 mL | 128.8461 mL |
| 5 mM | 1.0308 mL | 5.1538 mL | 10.3077 mL | 25.7692 mL | |
| 10 mM | 0.5154 mL | 2.5769 mL | 5.1538 mL | 12.8846 mL | |
| 15 mM | 0.3436 mL | 1.7179 mL | 3.4359 mL | 8.5897 mL | |
| 20 mM | 0.2577 mL | 1.2885 mL | 2.5769 mL | 6.4423 mL | |
| 25 mM | 0.2062 mL | 1.0308 mL | 2.0615 mL | 5.1538 mL | |
| 30 mM | 0.1718 mL | 0.8590 mL | 1.7179 mL | 4.2949 mL | |
| 40 mM | 0.1288 mL | 0.6442 mL | 1.2885 mL | 3.2212 mL | |
| 50 mM | 0.1031 mL | 0.5154 mL | 1.0308 mL | 2.5769 mL | |
| 60 mM | 0.0859 mL | 0.4295 mL | 0.8590 mL | 2.1474 mL | |
| 80 mM | 0.0644 mL | 0.3221 mL | 0.6442 mL | 1.6106 mL | |
| 100 mM | 0.0515 mL | 0.2577 mL | 0.5154 mL | 1.2885 mL |
Bromo-PEG1-C2-azide 関連分類
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