BTK-IN-8
BTK-IN-8 is a potent and selective peripheral covalent BTK inhibitor (IC50=0.22 nM; Kd=0.91 nM). BTK-IN-8 has good whole blood CD69 cellular potency (IC50=0.029 µM).
For research use only. We do not sell to patients.
- CAS No.: 2824922-28-1
- Formula: C26H36N6O3
- Molecular Weight:480.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
IC50: 0.22 nM (BTK)[1]
In Vitro
BTK-IN-8 (compound 42) shows potent target occupancy in Ramos cells (IC50=3.1 nM) and inhibits BTK-dependent TMD8 cells proliferation (IC50= 1.6 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 2824922-28-1
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Molecular Weight 480.60
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Formula C26H36N6O3
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SMILES
CC(C)CN(CC1=O)CCN1CC(C(C)=C2)=CC=C2C(N=CN=C3N)=C3OCCN(C)C(C=C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BTK-IN-8 Related Classifications
HY-145884 Related Classifications
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