BTK-IN-8
BTK-IN-8 is a potent and selective peripheral covalent BTK inhibitor (IC50=0.22 nM; Kd=0.91 nM). BTK-IN-8 has good whole blood CD69 cellular potency (IC50=0.029 µM).
For research use only. We do not sell to patients.
- CAS No.: 2824922-28-1
- Formula: C26H36N6O3
- Molecular Weight:480.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 0.22 nM (BTK)[1]
BTK-IN-8 (compound 42) shows potent target occupancy in Ramos cells (IC50=3.1 nM) and inhibits BTK-dependent TMD8 cells proliferation (IC50= 1.6 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2824922-28-1
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Molecular Weight 480.60
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Formula C26H36N6O3
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SMILES
CC(C)CN(CC1=O)CCN1CC(C(C)=C2)=CC=C2C(N=CN=C3N)=C3OCCN(C)C(C=C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BTK-IN-8 Related Classifications
HY-145884 Related Classifications
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