SPB
Based on 1 Customer Validation
SPB is a agent-linker conjugate for ADC with potent anti-inflammatory activity by using Xanthotoxol, linked via the ADC linker.
For research use only. We do not sell to patients.
- Purity: 95.00%
- CAS No.: 858128-57-1
- Formula: C19H15NO8
- Molecular Weight:385.32
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
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HY-13631E
Deruxtecan
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HY-100374
Val-Cit-PAB-MMAE
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HY-101141
sulfo-SPDB-DM4
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HY-13631EG
Deruxtecan (GMP)
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HY-12460
SPDB-DM4
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HY-79256
MMAF-OMe
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HY-112100
MC-Val-Cit-PAB-PROTAC ERα Degrader-1
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HY-128899
MC-Val-Cit-PAB-Auristatin E
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HY-100374G
Val-Cit-PAB-MMAE (GMP)
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HY-104025R
SPB (Standard)
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HY-101141R
sulfo-SPDB-DM4 (Standard)
All Drug-Linker Conjugates for ADC Isoforms
More
Biological Activity
Chemical Information
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CAS No. 858128-57-1
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Appearance Solid
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Molecular Weight 385.32
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Formula C19H15NO8
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Color Light yellow to yellow
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SMILES
O=C(ON1C(CCC1=O)=O)CCCOC2=C(O3)C(C=CC3=O)=CC4=C2OC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (129.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (247 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5952 mL | 12.9762 mL | 25.9525 mL | 64.8811 mL |
| 5 mM | 0.5190 mL | 2.5952 mL | 5.1905 mL | 12.9762 mL | |
| 10 mM | 0.2595 mL | 1.2976 mL | 2.5952 mL | 6.4881 mL | |
| 15 mM | 0.1730 mL | 0.8651 mL | 1.7302 mL | 4.3254 mL | |
| 20 mM | 0.1298 mL | 0.6488 mL | 1.2976 mL | 3.2441 mL | |
| 25 mM | 0.1038 mL | 0.5190 mL | 1.0381 mL | 2.5952 mL | |
| 30 mM | 0.0865 mL | 0.4325 mL | 0.8651 mL | 2.1627 mL | |
| 40 mM | 0.0649 mL | 0.3244 mL | 0.6488 mL | 1.6220 mL | |
| 50 mM | 0.0519 mL | 0.2595 mL | 0.5190 mL | 1.2976 mL | |
| 60 mM | 0.0433 mL | 0.2163 mL | 0.4325 mL | 1.0814 mL | |
| 80 mM | 0.0324 mL | 0.1622 mL | 0.3244 mL | 0.8110 mL | |
| 100 mM | 0.0260 mL | 0.1298 mL | 0.2595 mL | 0.6488 mL |
SPB Related Classifications
HY-104025 Related Classifications
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