Antitrypanosomal agent 9
Based on 1 Customer Validation
Antitrypanosomal agent 9 (compound 1) is a potent antitrypanosomal agent. Antitrypanosomal agent 9 shows inhibitory activity against T. b. brucei, with an IC50 of 1.15 μM. Antitrypanosomal agent 9 can be used for human African trypanosomiasis (HAT) research.
For research use only. We do not sell to patients.
- Purity: 90%
- CAS No.: 438474-67-0
- Formula: C22H27NO3
- Molecular Weight:353.45
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Trypanosoma |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
1.15 μM
Compound: 1
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Antitrypanosomal activity against Trypanosoma brucei brucei infected in HEK293 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
Antitrypanosomal activity against Trypanosoma brucei brucei infected in HEK293 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
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10.1039/C4MD00406J |
| L6 | IC50 |
107 μM
Compound: 1
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Antitrypanosomal activity against trypomastigote form of Trypanosoma cruzi Tulahuen C2C4 infected in rat L6 cells assessed as growth inhibition after 96 hrs by beta-galactosidase reporter gene assay
Antitrypanosomal activity against trypomastigote form of Trypanosoma cruzi Tulahuen C2C4 infected in rat L6 cells assessed as growth inhibition after 96 hrs by beta-galactosidase reporter gene assay
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10.1039/C4MD00406J |
| L6 | IC50 |
186 μM
Compound: 1
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Cytotoxicity against rat L6 cells after 70 hrs by resazurin dye-based fluorometric analysis
Cytotoxicity against rat L6 cells after 70 hrs by resazurin dye-based fluorometric analysis
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10.1039/C4MD00406J |
Antitrypanosomal agent 9 (compound 1) shows inhibitory activity against T. b. rhodesiense, T. cruzi, L. donovani, and P. falciparum, with IC50 values of 0.985 ± 0.076, 107 ± 34.5, 35.7 ± 6.22, and 22.3 ± 1.06 μM, respectively[1].
Antitrypanosomal agent 9 shows cytotoxicity in L6 cells, with an IC50 of 186 ± 94.2 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 438474-67-0
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Appearance Powder
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Molecular Weight 353.45
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Formula C22H27NO3
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Color Light brown to brown
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SMILES
N1(CCCC(C)C1)C(=O)C1C=CC(COC2C=CC(OCC)=CC=2)=CC=1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (267 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitrypanosomal agent 9 Related Classifications
HY-Q40175 Related Classifications
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