BDW568
Based on 1 Customer Validation
BDW568 is a selective STINGA230 agonist with an EC50 of 5.7 μM. BDW568 triggers the interferon signaling pathway and induces the expression of interferon-stimulated genes including MX1 and OAS1. BDW568 is applicable for cancer-related research.
For research use only. We do not sell to patients.
- Purity: 99.4%
- CAS No.: 335401-44-0
- Formula: C12H12N4O2S2
- Molecular Weight:308.38
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
BDW568 activates the STINGA230-mediated type I interferon signaling pathway in THP-1 cells, with an EC50 of 5.7 μM[2].
BDW568 (50 μM; 6 h) significantly upregulates the expression of MX1 and OAS1 in THP-1 cells[2].
BDW568 (serial dilution; 48 h) potently activates the STING pathway in THP-1 cells expressing STINGHAQ, with an EC50 of 5.7 μM[3].
BDW568 (50 μM; 6 h) significantly upregulates the interferon-stimulated genes MX1 and OAS1 in THP-1 cells expressing STINGHAQ[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:THP-1 cells (homozygous STINGHAQ genotype)
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Concentration:50 μM
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Incubation Time:6 h
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Result:Induced elevated expression of ISGs MX1 and OAS1, with MX1 showing a relative mRNA expression level ~100-fold higher than mock-treated cells.
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Cell Line:THP-1 cells (homozygous STINGHAQ)
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Concentration:50 μM
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Incubation Time:6 h
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Result:Robustly elevated MX1 and OAS1 mRNA expression relative to vehicle-treated cells.
Chemical Information
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CAS No. 335401-44-0
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Appearance Solid
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Molecular Weight 308.38
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Formula C12H12N4O2S2
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Color White to off-white
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SMILES
COC(CSC1=NN=C2N1C=NC3=C2C(C)=C(C)S3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Ling X, et al. Innovative CRISPR Screening Promotes Drug Target Identification. ACS Cent Sci. 2022 Nov 23;8(11):1477-1479. [Content Brief]
[2]. Tang Z, et al. Structural Evaluations of a Selective Human STINGA230 Agonist and Its Use in Macrophage Immunotherapies. ACS Med Chem Lett. 2024;15(5):653-658. Published 2024 Apr 12. [Content Brief]
[3]. Tang Z, et al. Structural and Biological Evaluations of a Non-Nucleoside STING Agonist Specific for Human STINGA230 Variants. bioRxiv [Preprint]. 2023 Jul 10:2023.07.02.547363. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BDW568 Related Classifications
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