Clesrovimab
Based on 3 publication(s) in Google Scholar
Clesrovimab (MK1654) is a humanized IgG1 monoclonal antibody targeting the respiratory syncytial virus (RSV) protein F. Clesrovimab binds to pre-fusion and post-fusion forms of RSV-A fusion protein with high affinity, with corresponding KD values of 71 pM and 480 pM, respectively. Clesrovimab is applicable for the research of RSV infection.
For research use only. We do not sell to patients.
- Purity: 99.77%
- CAS No.: 2429913-18-6
- Molecular Weight:146.75 kDa
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Clesrovimab
More
Biological Activity
Human IgG1 kappa
Human
RSV-F
Clesrovimab potently neutralizes historical and contemporary RSV A and B isolates in Hep-2 cells, with median EC50 values of 25 pM, 30 pM, 121 pM, and 130 pM for historical RSV A, historical RSV B, contemporary RSV A, and contemporary RSV B isolates, respectively[1].
Clesrovimab selects for resistant variants during in vitro serial passage of RSV A and RSV B, with >3800-fold reduced susceptibility in RSV A variants and >360-fold reduced susceptibility in an RSV B variant[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
A0A0X8XRK2
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
-
Human IgG1 kappa
ELISA, FACS, Functional assay
-
Immobilized Fusion glycoprotein F0/F Protein, HRSV (sf9, His, HY-P75182) can bind Clesrovimab. The EC50 for this effect is 4.686 ng/mL.
Chemical Information
-
CAS No. 2429913-18-6
-
Appearance Liquid
-
Molecular Weight 146.75 kDa
-
Color Colorless to light yellow
-
SMILES
[Clesrovimab]
-
Synonyms
MK1654
-
Shipping
Shipping with dry ice.
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
-
Journal Impact Factor
-
Most Recent
-
J Infect Dis
Respiratory Syncytial Virus Fusion Protein Epitope-specific Antibodies and Neutralizing Activities against Various Respiratory Syncytial Virus Strains. [Abstract]2025 Jul 18:jiaf375. PMID: 40675573 -
J Infect Dis
Amino acid substitutions in the fusion protein of respiratory syncytial virus in Fukushima, Japan during 2008-2023 and their effects. [Abstract]2024 Dec 24:jiae636. PMID: 39719011 -
Purity & Documentation
-
Data Sheet (259 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
-
Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz