c-Myc NLS
c-Myc NLS is a non-canonical nuclear localization signal (NLS) derived from the oncoprotein c-Myc, with the sequence PAAKRVKLD and containing 3 basic amino acids. c-Myc NLS mediates the nuclear localization of fusion proteins, and all its regions are essential or play important roles in nuclear import. c-Myc NLS can target fused pyruvate kinase to the nuclei of transfected cells.
For research use only. We do not sell to patients.
- CAS No.: 253328-16-4
- Formula: C44H80N14O12
- Molecular Weight:997.19
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
c-Myc NLS directs recombinant chicken pyruvate kinase to localize in the nuclei of transfected COS7 cells, in which the upstream PAA tripeptide and downstream LD dipeptide play critical or important roles in efficient nuclear localization[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 253328-16-4
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Molecular Weight 997.19
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Formula C44H80N14O12
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SMILES
O=C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]1NCCC1
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Sequence
Pro-Ala-Ala-Lys-Arg-Val-Lys-Leu-Asp
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Sequence Shortening
PAAKRVKLD
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
c-Myc NLS Related Classifications
HY-P11948 Related Classifications
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