Crizotinib-d9
Crizotinib-d9 (PF-02341066-d9) is deuterium labeled Crizotinib. Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition.
For research use only. We do not sell to patients.
- CAS No.: 1523580-59-7
- Formula: C21H13D9Cl2FN5O
- Molecular Weight:459.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1523580-59-7
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Unlabeled Cas 877399-52-5
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Molecular Weight 459.39
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Formula C21H13D9Cl2FN5O
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SMILES
C[C@H](C1=C(C(F)=CC=C1Cl)Cl)OC2=CC(C3=CN(C4([2H])C([2H])([2H])C([2H])([2H])NC([2H])([2H])C4([2H])[2H])N=C3)=CN=C2N
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Synonyms
PF-02341066-d9
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Crizotinib-d9 Related Classifications
HY-50878S2 Related Classifications
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