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Cat. No.: HY-148969

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FPPS-IN-1

FPPS-IN-1 is a potent non-bisphosphonate Farnesyl pyrophosphate synthase (FPPS) inhibitor with an IC₅₀ 0.2 μM. FPPS-IN-1 can be used for the research of cancers.

For research use only. We do not sell to patients.

CAS No.: 1250273-31-4
Formula: C₁₅H₁₁NO₄
Molecular Weight:269.26

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

FPPS-IN-1 Chemical Structure

CAS No.: 1250273-31-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

FPPS-IN-1 is a potent non-bisphosphonate Farnesyl pyrophosphate synthase (FPPS) inhibitor with an IC₅₀ 0.2 μM. FPPS-IN-1 can be used for the research of cancers^[1].

In Vitro

FPPS-IN-1 (compound 11) has low trans-cellular permeability, medium-to-low Caco-2 permeability, and no measurable bone affinity^[1].
FPPS-IN-1 (30 μM) shows no hERG channel inhibition^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 1250273-31-4
Molecular Weight 269.26
Formula C₁₅H₁₁NO₄
SMILES

O=C(O)C1=CC=2C=CC=3C=CC=CC3C2N1CC(=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Jahnke W, et al. Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery. Nat Chem Biol. 2010;6(9):660-666. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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