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UBAC1 - UBA domain containing 1 Gene

Also Known as KPC2; GBDR1; UBADC1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10422

About UBAC1

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:135,932,969-135,961,373 (from NCBI)

This gene has 6 transcripts (splice variants), 201 orthologues and 5 paralogues. Ubiquitous expression in bone marrow (RPKM 32.5), testis (RPKM 24.1) and 25 other tissues.

Summary

Predicted to be involved in protein ubiquitination. Located in Golgi apparatus; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

UBAC1 Products (1)

mRNA	Protein	Name
NM_016172.3	NP_057256.2	ubiquitin-associated domain-containing protein 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables polyubiquitin modification-dependent protein binding	IDA IDA: Inferred from direct assay	16227581	GOA
enables proteasome binding	IDA IDA: Inferred from direct assay	16227581	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein maturation	IDA IDA: Inferred from direct assay	25860612	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	16227581	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBAC1 Protein Structure

UBA

0
100
200
300
405 a.a.

Protein Preferred Names	Protein Names
ubiquitin-associated domain-containing protein 1	E3 ubiquitin-protein ligase subunit KPC2

UBAC1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	UBAC1	Q9BSL1	MCM10	Homo sapiens	Q7L590-2	Y2H Prey Pooling	32296183
Intra	UBAC1	Q9BSL1	MCM10	Homo sapiens	Q7L590-2	Y2H Array	32296183
Intra	UBAC1	Q9BSL1	RNF123	Homo sapiens	Q5XPI4	Anti Bait CoIP	17353931
Intra	UBAC1	Q9BSL1	RNF123	Homo sapiens	Q5XPI4	Anti Tag CoIP	33961781
Intra	UBAC1	Q9BSL1	RNF123	Homo sapiens	Q5XPI4	Anti Tag CoIP	28514442
Intra	UBAC1	Q9BSL1	CCDC138	Homo sapiens	Q96M89-2	Y2H Array	32296183
Intra	UBAC1	Q9BSL1	CCDC138	Homo sapiens	Q96M89-2	Y2H Prey Pooling	32296183
Intra	UBAC1	Q9BSL1	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	UBAC1	Q9BSL1	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	UBAC1	Q9BSL1	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	UBAC1	Q9BSL1	POU6F2	Homo sapiens	P78424	Y2H Array	32296183
Intra	UBAC1	Q9BSL1	POU6F2	Homo sapiens	P78424	Y2H Prey Pooling	32296183
Intra	UBAC1	Q9BSL1	PLAAT2	Homo sapiens	Q9NWW9	Validated Y2H	32296183
Intra	UBAC1	Q9BSL1	PLAAT2	Homo sapiens	Q9NWW9	Y2H Array	32296183
Intra	UBAC1	Q9BSL1	PLAAT2	Homo sapiens	Q9NWW9	Y2H Prey Pooling	32296183
Intra	UBAC1	Q9BSL1	MGAT3	Homo sapiens	Q09327	Y2H Prey Pooling	32296183
Intra	UBAC1	Q9BSL1	MGAT3	Homo sapiens	Q09327	Y2H Array	32296183
Intra	UBAC1	Q9BSL1	PSEN2	Homo sapiens	P49810	Y2H Array	32814053
Intra	UBAC1	Q9BSL1	PSEN2	Homo sapiens	P49810	Validated Y2H	32814053
Intra	UBAC1	Q9BSL1	PSEN2	Homo sapiens	P49810	Y2H Pooling	32814053
Intra	UBAC1	Q9BSL1	DCTN1	Homo sapiens	Q14203-5	Y2H Pooling	32814053
Intra	UBAC1	Q9BSL1	DCTN1	Homo sapiens	Q14203-5	Validated Y2H	32814053
Intra	UBAC1	Q9BSL1	DCTN1	Homo sapiens	Q14203-5	Y2H Array	32814053
Intra	UBAC1	Q9BSL1	ALS2	Homo sapiens	A0A0S2Z5Q7	Validated Y2H	32814053
Intra	UBAC1	Q9BSL1	ALS2	Homo sapiens	A0A0S2Z5Q7	Y2H Array	32814053
Intra	UBAC1	Q9BSL1	ALS2	Homo sapiens	A0A0S2Z5Q7	Y2H Pooling	32814053
Intra	UBAC1	Q9BSL1	SPART	Homo sapiens	Q8N0X7	Y2H Prey Pooling	32296183
Intra	UBAC1	Q9BSL1	SPART	Homo sapiens	Q8N0X7	Y2H Array	32296183
Intra	UBAC1	Q9BSL1	UBC	Homo sapiens	P0CG48	Y2H Prey Pooling	32296183
Intra	UBAC1	Q9BSL1	UBC	Homo sapiens	P0CG48	Y2H Array	32296183
Intra	UBAC1	Q9BSL1	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	UBAC1	Q9BSL1	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	UBAC1	Q9BSL1	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	UBAC1	Q9BSL1	UBB	Homo sapiens	P0CG47	Anti Tag CoIP	28514442
Intra	UBAC1	Q9BSL1	UBB	Homo sapiens	P0CG47	Y2H Prey Pooling	32296183
Intra	UBAC1	Q9BSL1	UBB	Homo sapiens	P0CG47	Y2H Array	32296183
Intra	UBAC1	Q9BSL1	UBB	Homo sapiens	P0CG47	Anti Tag CoIP	33961781
Intra	UBAC1	Q9BSL1	UCHL1	Homo sapiens	P09936	Y2H Pooling	32814053
Intra	UBAC1	Q9BSL1	UCHL1	Homo sapiens	P09936	Validated Y2H	32814053
Intra	UBAC1	Q9BSL1	UCHL1	Homo sapiens	P09936	Y2H Array	32814053
Intra	UBAC1	Q9BSL1	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	UBAC1	Q9BSL1	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	UBAC1	Q9BSL1	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	UBAC1	Q9BSL1	RNF216	Homo sapiens	Q9NWF9	Validated Y2H	32296183
Intra	UBAC1	Q9BSL1	RNF216	Homo sapiens	Q9NWF9	Y2H Array	32296183
Intra	UBAC1	Q9BSL1	RNF216	Homo sapiens	Q9NWF9	Y2H Prey Pooling	32296183
Intra	UBAC1	Q9BSL1	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
Intra	UBAC1	Q9BSL1	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
Intra	UBAC1	Q9BSL1	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	25416956
Intra	UBAC1	Q9BSL1	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	UBAC1	Q9BSL1	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	UBAC1	Q9BSL1	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	UBAC1	Q9BSL1	TRIM2	Homo sapiens	Q9C040	Validated Y2H	25416956
Intra	UBAC1	Q9BSL1	TRIM2	Homo sapiens	Q9C040	Y2H Array	32296183
Intra	UBAC1	Q9BSL1	TRIM2	Homo sapiens	Q9C040	Y2H Array	25416956
Intra	UBAC1	Q9BSL1	TRIM2	Homo sapiens	Q9C040	Y2H	21516116
Intra	UBAC1	Q9BSL1	TRIM2	Homo sapiens	Q9C040	Y2H Prey Pooling	25416956
Intra	UBAC1	Q9BSL1	TRIM2	Homo sapiens	Q9C040	Y2H Prey Pooling	32296183
Intra	UBAC1	Q9BSL1	TRIM2	Homo sapiens	Q9C040	Validated Y2H	32296183
Intra	UBAC1	Q9BSL1	IGFBP6	Homo sapiens	P24592	Y2H Array	32296183
Intra	UBAC1	Q9BSL1	IGFBP6	Homo sapiens	P24592	Y2H Prey Pooling	32296183
Intra	UBAC1	Q9BSL1	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	UBAC1	Q9BSL1	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	UBAC1	Q9BSL1	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UBAC1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700392	UBAC1 Protein, Human (GST)	Q9BSL1 (M1-T405)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Urinary Tract Infection	Urinary Tract Infections Uti Urinary Tract Infection Nos Uti - [Urinary Tract Infection] Uti Nos - [Urinary Tract Infection Nos] Urosepsis Nos E Coli Uti E Coli Urinary Tract Infection Escherichia Coli Uti
Pyelitis
Acute Pyelonephritis	Apn - [Acute Pyelonephritis]
Granulomatous Disease, Chronic, Autosomal Recessive, 3	CGD3 Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type Iii Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 3 Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Iii Cgd, Autosomal Recessive Cytochrome B-Positive, Type Iii Granulomatous Disease, Chronic, Due To Ncf4 Deficiency Chronic Granulomatous Disease 3, Autosomal Recessive Autosomal Recessive Chronic Granulomatous Disease 3 Autosomal Recessive Cytochrome B-Positive Cgd Type Iii Cdg3 Chronic Granulomatous Disease Due To Ncf4 Deficiency Cgd Autosomal Recessive Cytochrome B-Positive Type Iii Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type Iii Granulomatous Disease Chronic Due To Ncf4 Deficiency Granulomatous Disease, Chronic, Autosomal Recessive Cytochrome B-Positive, Type 3
Blood Group, Globoside System	Globe Disease GLOB Blood Group System, Globoside
Parametritis	Pelvic Cellulitis
Myasthenic Syndrome, Congenital, 9, Associated With Acetylcholine Receptor Deficiency	Congenital Myasthenic Syndrome 9 CMS9 Congenital Myasthenic Syndrome 9, Associated With Acetylcholine Receptor Deficiency Myasthenic Syndrome, Congenital, Type 9, Associated With Acetylcholine Receptor Deficiency
Endophthalmitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15326	UBAC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22891	Ubac1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	UBAC1	MGD	MGI:1920995
Macaca mulatta	UBAC1	VGNC	VGNC:79837
Canis familiaris	UBAC1	VGNC	VGNC:48042
Felis catus	UBAC1	VGNC	VGNC:66752
Rattus norvegicus	UBAC1	RGD	RGD:1359542
Bos taurus	UBAC1	VGNC	VGNC:36567
Others	UBAC1	NCBI