FRMD3 - FERM domain containing 3 Gene
Also Known as 4.1O; P410; EPB41LO; EPB41L4O
Species: Homo sapiens
About FRMD3
This gene has 7 transcripts (splice variants), 228 orthologues and 10 paralogues. Broad expression in heart (RPKM 8.0), kidney (RPKM 5.0) and 20 other tissues.
Summary
The protein encoded by this gene is a single pass membrane protein primarily found in ovaries. A similar protein in erythrocytes helps determine the shape of red blood cells, but the function of the encoded protein has not been determined. There is some evidence that this is a tumor suppressor gene, and there is also evidence linking defects in this gene to susceptibility to diabetic nephropathy in type 1 diabetes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
FRMD3 Products (6)
| mRNA | Protein | Name |
|---|---|---|
| NM_001244959.2 | NP_001231888.1 | FERM domain-containing protein 3 isoform 2 |
| NM_001244960.2 | NP_001231889.1 | FERM domain-containing protein 3 isoform 3 |
| NM_001244961.2 | NP_001231890.1 | FERM domain-containing protein 3 isoform 4 |
| NM_001244962.2 | NP_001231891.1 | FERM domain-containing protein 3 isoform 5 |
| NM_001375487.1 | NP_001362416.1 | FERM domain-containing protein 3 isoform 6 |
| NM_174938.6 | NP_777598.3 | FERM domain-containing protein 3 isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
32296183 | GOA |
FRMD3 Protein Structure
FERM_N: FERM N-terminal domain (36 - 113)
FERM_M: FERM central domain (116 - 225)
FERM_C: FERM C-terminal PH-like domain (229 - 314)
FA: FERM adjacent (FA) (322 - 368)
- 0
- 100
- 200
- 300
- 400
- 500
- 597 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
FERM domain-containing protein 3 |
|
FRMD3 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
FRMD3 | A2A2Y4 | TMEM218 | Homo sapiens | A2RU14 | 32296183 | |
|
Intra
|
FRMD3 | A2A2Y4 | NRM | Homo sapiens | Q8IXM6 | 32296183 | |
|
Intra
|
FRMD3 | A2A2Y4 | JAGN1 | Homo sapiens | Q8N5M9 | 32296183 | |
|
Intra
|
FRMD3 | A2A2Y4 | SERP1 | Homo sapiens | Q9Y6X1 | 32296183 | |
|
Intra
|
FRMD3 | A2A2Y4 | PLPP4 | Homo sapiens | Q5VZY2 | 32296183 | |
|
Intra
|
FRMD3 | A2A2Y4 | CYB5B | Homo sapiens | O43169 | 32296183 | |
|
Intra
|
FRMD3 | A2A2Y4 | TMEM201 | Homo sapiens | Q5SNT2-2 | 32296183 | |
|
Intra
|
FRMD3 | A2A2Y4 | TMEM97 | Homo sapiens | Q5BJF2 | 32296183 | |
|
Intra
|
FRMD3 | A2A2Y4 | SLC35A4 | Homo sapiens | Q96G79 | 32296183 | |
|
Intra
|
FRMD3 | A2A2Y4 | CMTM7 | Homo sapiens | Q96FZ5 | 32296183 | |
|
Intra
|
FRMD3 | A2A2Y4 | ZFPL1 | Homo sapiens | O95159 | 32296183 | |
|
Intra
|
FRMD3 | A2A2Y4 | SERP2 | Homo sapiens | Q8N6R1 | 32296183 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Hypertropia |
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | FRMD3 | VGNC | VGNC:40979 |
| Rattus norvegicus | FRMD3 | RGD | RGD:1304802 |
| Mus musculus | FRMD3 | MGD | MGI:2442466 |
| Macaca mulatta | FRMD3 | VGNC | VGNC:72769 |
| Bos taurus | FRMD3 | VGNC | VGNC:29113 |
| Felis catus | FRMD3 | VGNC | VGNC:62359 |
| Others | FRMD3 | NCBI |