AVPR1A - arginine vasopressin receptor 1A Gene

Also Known as V1aR; AVPR1; AVPR V1a

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 552

About AVPR1A

Cytogenetic location: 12q14.2 Genomic coordinates (GRCh38): 12:63,142,759-63,151,201 (from NCBI)

This gene has 2 transcripts (splice variants), 264 orthologues and 16 paralogues. Biased expression in adrenal (RPKM 29.7), endometrium (RPKM 8.7) and 7 other tissues.

Summary

The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis. [provided by RefSeq, Jul 2008]

AVPR1A Products (1)

mRNA	Protein	Name
NM_000706.5	NP_000697.1	vasopressin V1a receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18402937	GOA
enables vasopressin receptor activity	IDA IDA: Inferred from direct assay	9322919	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	9322919	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endocytic vesicle	IDA IDA: Inferred from direct assay	14757828	GOA
located in endosome	IDA IDA: Inferred from direct assay	14757828	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	14757828	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AVPR1A Protein Structure

7tm_1

DUF1856

0
100
200
300
400
418 a.a.

Protein Preferred Names	Protein Names
vasopressin V1a receptor	SCCL vasopressin subtype 1a receptor V1-vascular vasopressin receptor AVPR1A V1a vasopressin receptor antidiuretic hormone receptor 1A vascular/hepatic-type arginine vasopressin receptor

AVPR1A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AVPR1A	P37288	ACKR3	Homo sapiens	P25106	Anti Bait CoIP	29386406
Intra	AVPR1A	P37288	ACKR3	Homo sapiens	P25106	PLA	29386406

Cross: Cross-species interaction Intra: Intraspecies interaction

AVPR1A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811281	Vasopressin V1a Receptor Antibody	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Personality Disorder	Personality Disorders Character Disorder Personality Specific Personality Disorders Enduring Personality Change After Psychiatric Illness
Diabetes Insipidus
Episodic Pain Syndrome, Familial, 1	FEPS1 Familial Episodic Pain Syndrome With Predominantly Upper Body Involvement Familial Episodic Pain Syndrome 1
Voyeurism
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Asperger Syndrome	Asperger Disorder
Panic Disorder	Panic Anxiety Syndrome Panic Panic Disorder 1 Episodic Paroxysmal Anxiety Disorder
X-Linked Nephrogenic Diabetes Insipidus	Nephrogenic Diabetes Insipidus Type 1 Doid:0081060
Nephrogenic Diabetes Insipidus	Vasopressin-Resistant Diabetes Insipidus Diabetes Insipidus, Nephrogenic Diabetes Insipidus Nephrogenic Congenital Nephrogenic Diabetes Insipidus Adh Resistant Diabetes Insipidus Diabetes Insipidus Nephrogenic X-Linked Diabetes Insipidus Nephrogenic Type 1 Adh-Resistant Diabetes Insipidus Diabetes Insipidus Renalis Ndi Renal Diabetes Insipidus Familial Nephrogenic Diabetes Antidiuretic-Hormone-Resistant Diabetes Insipidus Adiuretin-Resistant Diabetes Insipidus Ndi - [Nephrogenic Diabetes Insipidus] Diabetes Tenuifluus Adh - [Antidiuretic-Hormone] Resistant Diabetes Insipidus Hereditary Nephrogenic Diabetes Insipidus Familial Nephrogenic Diabetes Insipidus Primary Nephrogenic Diabetes Insipidus
Borderline Personality Disorder
Diabetes Insipidus, Neurohypophyseal	Neurohypophyseal Diabetes Insipidus Central Diabetes Insipidus Cdi Pituitary Diabetes Insipidus Vasopressin Defective Diabetes Insipidus Vasopressin Deficiency Diabetes Insipidus, Neurogenic Diabetes Insipidus, Primary Central Diabetes Insipidus, Cranial Type Diabetes Insipidus Secondary To Vasopressin Deficiency Diabetes Insipidus, Central Diabetes Insipidus, Pituitary NDI Diabetes Insipidus Cranial Type Neurogenic Diabetes Insipidus Primary Central Diabetes Insipidus
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Amusia	Receptive Amusia
Nephrogenic Syndrome Of Inappropriate Antidiuresis	NSIAD
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Pervasive Developmental Disorder	Pervasive Development Disorder Pervasive Developmental Disorders Pervasive Child Development Disorders Autistic Behavior Autism Spectrum Disorders
Hepatorenal Syndrome	Hepato-Renal Syndrome Hepatorenal Failure Hrf - [Hepatorenal Failure] Hepatorenal Degeneration Hepatic Renal Syndrome Hepatic Renal Failure Renal Hepatic Failure Urohepatic Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0049A	Argipressin diacetate		/	Unkown

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P4990	Pro8-Oxytocin	Activator	99.68%	Unkown
HY-P4990A	Pro8-Oxytocin TFA	Activator	99.68%	Unkown
HY-RS01281	AVPR1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01282	Avpr1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01283	Avpr1a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	AVPR1A	MGD	MGI:1859216
Canis familiaris	AVPR1A	VGNC	VGNC:38318
Rattus norvegicus	AVPR1A	RGD	RGD:2185
Felis catus	AVPR1A	VGNC	VGNC:68838
Macaca mulatta	AVPR1A	VGNC	VGNC:70197
Bos taurus	AVPR1A	VGNC	VGNC:26358
Others	AVPR1A	NCBI