SRSF6 - serine and arginine rich splicing factor 6 Gene

Also Known as B52; SFRS6; SRP55; HEL-S-91

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6431

About SRSF6

Cytogenetic location: 20q13.11 Genomic coordinates (GRCh38): 20:43,457,896-43,464,243 (from NCBI)

This gene has 6 transcripts (splice variants), 260 orthologues and 8 paralogues. Ubiquitous expression in bone marrow (RPKM 64.4), prostate (RPKM 51.8) and 25 other tissues.

Summary

The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12. Alternative splicing results in multiple transcript variants. In addition, two pseudogenes, one on chromosome 17 and the Other on the X chromosome, have been found for this gene.[provided by RefSeq, Sep 2010]

SRSF6 Products (1)

mRNA Protein Name
NM_006275.6 NP_006266.2 serine/arginine-rich splicing factor 6

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
24440982 GOA
enables pre-mRNA binding IDA
IDA: Inferred from direct assay
12549914 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in alternative mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
22767602 GOA
involved in mRNA splice site recognition IMP
IMP: Inferred from mutant phenotype
12549914 GOA
involved in negative regulation of keratinocyte differentiation IMP
IMP: Inferred from mutant phenotype
24440982 GOA
involved in negative regulation of mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
15009664 GOA
acts upstream of or within positive regulation of epithelial cell proliferation involved in lung morphogenesis IDA
IDA: Inferred from direct assay
23132731 GOA
acts upstream of or within regulation of alternative mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
23132731 GOA
involved in regulation of alternative mRNA splicing, via spliceosome IMP
IMP: Inferred from mutant phenotype
24440982 GOA
involved in regulation of keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
24440982 GOA
involved in regulation of wound healing IMP
IMP: Inferred from mutant phenotype
24440982 GOA
Cellular Component GO Annotation Evidence References Source
located in nuclear speck IDA
IDA: Inferred from direct assay
22767602 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRSF6 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (4 - 64)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (112 - 177)

  • 0
  • 100
  • 200
  • 300
  • 344 a.a.
Protein Preferred Names Protein Names

serine/arginine-rich splicing factor 6

  • SR splicing factor 6

SRSF6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SRSF6 Q13247 LUC7L2 Homo sapiens Q9Y383
Validated Y2H
25416956
Intra
SRSF6 Q13247 LUC7L2 Homo sapiens Q9Y383
Validated Y2H
32296183
Intra
SRSF6 Q13247 LUC7L2 Homo sapiens Q9Y383
Y2H Array
25416956
Intra
SRSF6 Q13247 LUC7L2 Homo sapiens Q9Y383
Y2H Array
31515488
Intra
SRSF6 Q13247 RNPS1 Homo sapiens Q15287
Y2H Pooling
16189514
Intra
SRSF6 Q13247 SRPK1 Homo sapiens Q96SB4
Anti Tag CoIP
33961781
Intra
SRSF6 Q13247 LUC7L Homo sapiens Q9NQ29-3
Validated Y2H
32296183
Intra
SRSF6 Q13247 SRSF4 Homo sapiens Q08170
Y2H Array
31515488
Intra
SRSF6 Q13247 SRSF4 Homo sapiens Q08170
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Plasmodium Malariae Malaria

  • Quartan Malaria

  • Malaria By Plasmodium Malariae

  • Nephrotic Syndrome Of Quartan Malaria

  • Malaria Nephrosis

  • Malarial Nephrosis

  • Nephrotic Syndrome In Malaria

  • Quartan Nephrosis
Aortitis
Cataract 30

  • Cataract 30 Pulverulent

  • Cataract Coppock-Like

  • Ctrct30

  • Dusty Cataract

  • Cataract, Type 30
Temporal Arteritis

  • Polymyalgia Rheumatica

  • Giant Cell Arteritis

  • Cranial Arteritis

  • Horton Disease

  • Gca

  • Horton'S Disease

  • Rhizomelic Pseudopolyarthritis

  • Arteritis Cranialis

  • Arteritis Temporalis

  • Horton'S Arteritis

  • Horton'S Giant Cell Arteritis

  • Horton'S Temporal Arteritis

  • Horton'S Syndrome

  • Gca - [Giant Cell Arteritis]

  • Senile Arthritis

  • Polymyalgia Arteritica

  • Pmr - [Polymyalgia Rheumatica]

  • Forestier-Certonciny Syndrome

  • Rheumatic Polymyalgia

  • Polymyalgia
Aortic Valve Insufficiency

  • Aortic Regurgitation

  • Rheumatic Aortic Regurgitation

  • Aortic Insufficiency

  • Rheumatic Aortic Insufficiency

  • Rheumatic Aortic Valve Insufficiency

  • Aortic Incompetence

  • Corrigan'S Disease

  • Rheumatic Aortic Valve Regurgitation

  • Aortic Valve Incompetency

  • Ai - [Aortic Incompetence]

  • Incompetent Aortic Valve

  • Ar - [Aortic Regurgitation]

  • Calcific Aortic Valve Regurgitation

  • Myxomatous Aortic Valve Regurgitation

  • Annular Incompetency Of Aortic Valve

  • Austin Flint Murmur

  • Flint Murmur

  • Rheumatic Aortic Incompetence

  • Rheumatic Ai - [Aortic Insufficiency]
Denys-Drash Syndrome

  • Drash Syndrome

  • DDS

  • Nephropathy, Wilms Tumor, And Genital Anomalies

  • Wilms Tumor And Pseudohermaphroditism

  • Wilms Tumor And Pseudo- Or True Hermaphroditism

  • Nephropathy Associated With Male Pseudohermaphroditism And Wilms' Tumor

  • Pseudohermaphroditism, Nephron Disorder And Wilms' Tumor

  • Wilms Tumor-Dsd Syndrome

  • Wilms Tumor-Disorder Of Sex Development Syndrome
Behcet Syndrome

  • Behcet Disease

  • Behcet'S Syndrome

  • Behcet'S Disease

  • Behçet Disease

  • Bd

  • Adamantiades-Behcet Disease

  • Triple Symptom Complex

  • Behçet'S Disease

  • Behet'S Syndrome

  • Bd Syndrome

  • Behçet Syndrome

  • Behçet'S Syndrome

  • Behcet Triple Symptom Complex

  • Malignant Aphthosis

  • Old Silk Route Disease

  • Adamantiades-Behçet Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13797 SRSF6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21053 Srsf6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27571 Srsf6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SRSF6 VGNC VGNC:54735
Mus musculus SRSF6 MGD MGI:1915246
Rattus norvegicus SRSF6 RGD RGD:1359241
Bos taurus SRSF6 VGNC VGNC:57028
Macaca mulatta SRSF6 VGNC VGNC:77821
Others SRSF6 NCBI